Cargando…

CD8(+) T-Cells as Immune Regulators of Multiple Sclerosis

The vast majority of studies regarding the immune basis of MS (and its animal model, EAE) have largely focused on CD4(+) T-cells as mediators and regulators of disease. Interestingly, CD8(+) T-cells represent the predominant T-cell population in human MS lesions and are oligoclonally expanded at the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sinha, Sushmita, Boyden, Alexander W., Itani, Farah R., Crawford, Michael P., Karandikar, Nitin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674574/ https://www.ncbi.nlm.nih.gov/pubmed/26697014 http://dx.doi.org/10.3389/fimmu.2015.00619

Ejemplares similares

IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation
por: Renavikar, Pranav S., et al.
Publicado: (2020)

Early IFNγ-Mediated and Late Perforin-Mediated Suppression of Pathogenic CD4 T Cell Responses Are Both Required for Inhibition of Demyelinating Disease by CNS-Specific Autoregulatory CD8 T Cells
por: Boyden, Alexander W., et al.
Publicado: (2018)

Therapeutic intervention in relapsing autoimmune demyelinating disease through induction of myelin-specific regulatory CD8 T cell responses
por: Brate, Ashley A., et al.
Publicado: (2019)

Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen
por: Itani, Farah R., et al.
Publicado: (2017)

Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein
por: Boyden, Alexander W., et al.
Publicado: (2020)

Involvement of CD8(+) T Cells in Multiple Sclerosis
por: Salou, Marion, et al.
Publicado: (2015)

Pathogenic CD8 T Cells in Multiple Sclerosis and Its Experimental Models
por: Huseby, Eric S., et al.
Publicado: (2012)

Activation of Blood CD3(+)CD56(+)CD8(+) T Cells during Pregnancy and Multiple Sclerosis
por: de Andrés, Clara, et al.
Publicado: (2017)

Loss of Circulating CD8+ CD161(high) T Cells in Primary Progressive Multiple Sclerosis
por: Acquaviva, Massimo, et al.
Publicado: (2019)

Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells
por: Tilly, Gaëlle, et al.
Publicado: (2021)

Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells
por: Sinha, Sushmita, et al.
Publicado: (2020)

An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells
por: Sinha, Sushmita, et al.
Publicado: (2018)

Prevotella histicola, A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis
por: Shahi, Shailesh K., et al.
Publicado: (2019)

Regulation of CD8(+) T Cells and Antitumor Immunity by Notch Signaling
por: Tsukumo, Shin-ichi, et al.
Publicado: (2018)

Characterization of antigen-specific CD8+ memory T cell subsets in peripheral blood of patients with multiple sclerosis
por: Liu, Pen-Ju, et al.
Publicado: (2023)

CD8+ T Cell-Mediated Mechanisms Contribute to the Progression of Neurocognitive Impairment in Both Multiple Sclerosis and Alzheimer's Disease?
por: Stojić-Vukanić, Zorica, et al.
Publicado: (2020)

Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants
por: Ortega, Sterling B., et al.
Publicado: (2015)

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis
por: Veroni, Caterina, et al.
Publicado: (2021)

Proinflammatory mucosal-associated invariant CD8+ T cells react to gut flora yeasts and infiltrate multiple sclerosis brain
por: Gargano, Francesca, et al.
Publicado: (2022)

Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases
por: Riedhammer, Christine, et al.
Publicado: (2015)

CD4(+)CD8(+) T follicular helper cells regulate humoral immunity in chronic inflammatory lesions
por: Murayama, Kosuke, et al.
Publicado: (2022)

Phenotypic Alterations Involved in CD8+ Treg Impairment in Systemic Sclerosis
por: Negrini, Simone, et al.
Publicado: (2017)

Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression
por: Peeters, Liesbet M., et al.
Publicado: (2017)

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
por: Aarts, Suzanne A. B. M., et al.
Publicado: (2017)

The Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple Sclerosis
por: Ignatius Arokia Doss, Prenitha Mercy, et al.
Publicado: (2015)

Commentary: CD6 As a Potential Target for Treating Multiple Sclerosis
por: Consuegra-Fernández, Marta, et al.
Publicado: (2017)

Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis
por: Killick, Justin, et al.
Publicado: (2020)

Anti-CD20 therapies in multiple sclerosis: From pathology to the clinic
por: de Sèze, Jérôme, et al.
Publicado: (2023)

Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis
por: Noll, Christina, et al.
Publicado: (2022)

IL-17 cytokines preferentially act on naïve CD4(+) T cells with the IL-17AF heterodimer inducing the greatest functional changes
por: Crawford, Michael P., et al.
Publicado: (2023)

NLR-Dependent Regulation of Inflammation in Multiple Sclerosis
por: Gharagozloo, Marjan, et al.
Publicado: (2018)

NFAT2 Regulates Generation of Innate-Like CD8(+) T Lymphocytes and CD8(+) T Lymphocytes Responses
por: Pachulec, Emilia, et al.
Publicado: (2016)

CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis
por: Hülskötter, Kirsten, et al.
Publicado: (2023)

CD3(+)CD4(-)CD8(-) (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer
por: Wu, Zhiheng, et al.
Publicado: (2022)

Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis
por: Rossi, Barbara, et al.
Publicado: (2016)

Common Peripheral Immunity Mechanisms in Multiple Sclerosis and Alzheimer's Disease
por: Rossi, Barbara, et al.
Publicado: (2021)

Mechanistic and Biomarker Studies to Demonstrate Immune Tolerance in Multiple Sclerosis
por: Docampo, María José, et al.
Publicado: (2022)

Immune cells transcriptome-based drug repositioning for multiple sclerosis
por: Yin, Xinyue, et al.
Publicado: (2022)

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging
por: Gustafson, Claire E., et al.
Publicado: (2017)

Erratum: NLR-Dependent Regulation of Inflammation in Multiple Sclerosis
por: Office, Frontiers Production
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_b1b9eu6eb0ubd3frq0a28s6cbf