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Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice

Three decades of electrophysiological research on cerebellar cortical activity underlying Pavlovian conditioning have expanded our understanding of motor learning in the brain. Purkinje cell simple spike suppression is considered to be crucial in the expression of conditional blink responses (CRs)....

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Autores principales: ten Brinke, Michiel M., Boele, Henk-Jan, Spanke, Jochen K., Potters, Jan-Willem, Kornysheva, Katja, Wulff, Peer, IJpelaar, Anna C.H.G., Koekkoek, Sebastiaan K.E., De Zeeuw, Chris I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674627/
https://www.ncbi.nlm.nih.gov/pubmed/26655909
http://dx.doi.org/10.1016/j.celrep.2015.10.057
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author ten Brinke, Michiel M.
Boele, Henk-Jan
Spanke, Jochen K.
Potters, Jan-Willem
Kornysheva, Katja
Wulff, Peer
IJpelaar, Anna C.H.G.
Koekkoek, Sebastiaan K.E.
De Zeeuw, Chris I.
author_facet ten Brinke, Michiel M.
Boele, Henk-Jan
Spanke, Jochen K.
Potters, Jan-Willem
Kornysheva, Katja
Wulff, Peer
IJpelaar, Anna C.H.G.
Koekkoek, Sebastiaan K.E.
De Zeeuw, Chris I.
author_sort ten Brinke, Michiel M.
collection PubMed
description Three decades of electrophysiological research on cerebellar cortical activity underlying Pavlovian conditioning have expanded our understanding of motor learning in the brain. Purkinje cell simple spike suppression is considered to be crucial in the expression of conditional blink responses (CRs). However, trial-by-trial quantification of this link in awake behaving animals is lacking, and current hypotheses regarding the underlying plasticity mechanisms have diverged from the classical parallel fiber one to the Purkinje cell synapse LTD hypothesis. Here, we establish that acquired simple spike suppression, acquired conditioned stimulus (CS)-related complex spike responses, and molecular layer interneuron (MLI) activity predict the expression of CRs on a trial-by-trial basis using awake behaving mice. Additionally, we show that two independent transgenic mouse mutants with impaired MLI function exhibit motor learning deficits. Our findings suggest multiple cerebellar cortical plasticity mechanisms underlying simple spike suppression, and they implicate the broader involvement of the olivocerebellar module within the interstimulus interval.
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spelling pubmed-46746272015-12-30 Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice ten Brinke, Michiel M. Boele, Henk-Jan Spanke, Jochen K. Potters, Jan-Willem Kornysheva, Katja Wulff, Peer IJpelaar, Anna C.H.G. Koekkoek, Sebastiaan K.E. De Zeeuw, Chris I. Cell Rep Article Three decades of electrophysiological research on cerebellar cortical activity underlying Pavlovian conditioning have expanded our understanding of motor learning in the brain. Purkinje cell simple spike suppression is considered to be crucial in the expression of conditional blink responses (CRs). However, trial-by-trial quantification of this link in awake behaving animals is lacking, and current hypotheses regarding the underlying plasticity mechanisms have diverged from the classical parallel fiber one to the Purkinje cell synapse LTD hypothesis. Here, we establish that acquired simple spike suppression, acquired conditioned stimulus (CS)-related complex spike responses, and molecular layer interneuron (MLI) activity predict the expression of CRs on a trial-by-trial basis using awake behaving mice. Additionally, we show that two independent transgenic mouse mutants with impaired MLI function exhibit motor learning deficits. Our findings suggest multiple cerebellar cortical plasticity mechanisms underlying simple spike suppression, and they implicate the broader involvement of the olivocerebellar module within the interstimulus interval. Cell Press 2015-11-19 /pmc/articles/PMC4674627/ /pubmed/26655909 http://dx.doi.org/10.1016/j.celrep.2015.10.057 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
ten Brinke, Michiel M.
Boele, Henk-Jan
Spanke, Jochen K.
Potters, Jan-Willem
Kornysheva, Katja
Wulff, Peer
IJpelaar, Anna C.H.G.
Koekkoek, Sebastiaan K.E.
De Zeeuw, Chris I.
Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice
title Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice
title_full Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice
title_fullStr Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice
title_full_unstemmed Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice
title_short Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice
title_sort evolving models of pavlovian conditioning: cerebellar cortical dynamics in awake behaving mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674627/
https://www.ncbi.nlm.nih.gov/pubmed/26655909
http://dx.doi.org/10.1016/j.celrep.2015.10.057
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