p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

Centriolar satellites (CS) are small granular structures that cluster in the vicinity of centrosomes. CS are highly susceptible to stress stimuli, triggering abrupt displacement of key CS factors. Here we discover a linear p38-MK2-14-3-3 signalling pathway that specifically targets CEP131 to trigger...

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Detalles Bibliográficos
Autores principales: Tollenaere, Maxim A. X., Villumsen, Bine H., Blasius, Melanie, Nielsen, Julie C., Wagner, Sebastian A., Bartek, Jiri, Beli, Petra, Mailand, Niels, Bekker-Jensen, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674683/
https://www.ncbi.nlm.nih.gov/pubmed/26616734
http://dx.doi.org/10.1038/ncomms10075

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