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Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so far...

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Detalles Bibliográficos
Autores principales:	Kim, Hanseong, An, Sojin, Ro, Seung-Hyun, Teixeira, Filipa, Jin Park, Gyeong, Kim, Cheal, Cho, Chun-Seok, Kim, Jeong-Sig, Jakob, Ursula, Hee Lee, Jun, Cho, Uhn-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674687/ https://www.ncbi.nlm.nih.gov/pubmed/26612684 http://dx.doi.org/10.1038/ncomms10025

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