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Antagonism of Na(v) channels and α(1)-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine
Ranolazine is a recently developed drug used for the treatment of patients with chronic stable angina. It is a selective inhibitor of the persistent cardiac Na(+) current (I(Na)), and is known to reduce the Na(+)-dependent Ca(2+) overload that occurs in cardiomyocytes during ischemia. Vascular effec...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674695/ https://www.ncbi.nlm.nih.gov/pubmed/26655634 http://dx.doi.org/10.1038/srep17969 |