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Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance
In the UK, patients undergo HIV viral load and genotype testing before they are prescribed antiretroviral therapy. The genotype test guides clinicians in prescribing antiretroviral therapy with maximum efficacy against the patient’s specific viral strain. HIV viral load escape under antiretroviral d...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674743/ https://www.ncbi.nlm.nih.gov/pubmed/25663247 http://dx.doi.org/10.1177/0956462415571671 |
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author | Martin, Fabiola Lee, John Thomson, Emma Tarrant, Nick Hale, Antony Lacey, Charles J |
author_facet | Martin, Fabiola Lee, John Thomson, Emma Tarrant, Nick Hale, Antony Lacey, Charles J |
author_sort | Martin, Fabiola |
collection | PubMed |
description | In the UK, patients undergo HIV viral load and genotype testing before they are prescribed antiretroviral therapy. The genotype test guides clinicians in prescribing antiretroviral therapy with maximum efficacy against the patient’s specific viral strain. HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two-newly diagnosed patients, during antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted infections. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch. |
format | Online Article Text |
id | pubmed-4674743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-46747432015-12-31 Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance Martin, Fabiola Lee, John Thomson, Emma Tarrant, Nick Hale, Antony Lacey, Charles J Int J STD AIDS Case Reports In the UK, patients undergo HIV viral load and genotype testing before they are prescribed antiretroviral therapy. The genotype test guides clinicians in prescribing antiretroviral therapy with maximum efficacy against the patient’s specific viral strain. HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two-newly diagnosed patients, during antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted infections. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch. SAGE Publications 2016-01 /pmc/articles/PMC4674743/ /pubmed/25663247 http://dx.doi.org/10.1177/0956462415571671 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Reports Martin, Fabiola Lee, John Thomson, Emma Tarrant, Nick Hale, Antony Lacey, Charles J Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance |
title | Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance |
title_full | Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance |
title_fullStr | Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance |
title_full_unstemmed | Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance |
title_short | Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance |
title_sort | two cases of possible transmitted drug-resistant hiv: likely hiv superinfection and unmasking of pre-existing resistance |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674743/ https://www.ncbi.nlm.nih.gov/pubmed/25663247 http://dx.doi.org/10.1177/0956462415571671 |
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