CRISPR/Cas9-mediated knockout of factors in non-homologous end joining pathway enhances gene targeting in silkworm cells

Gene targeting can be achieved by precise genetic modifications through homology-directed repair (HDR) after DNA breaks introduced by genome editing tools such as CRISPR/Cas9 system. The most common form of HDR is homologous recombination (HR). Binding to the DNA breaks by HR factors is thought to c...

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Detalles Bibliográficos
Autores principales: Zhu, Li, Mon, Hiroaki, Xu, Jian, Lee, Jae Man, Kusakabe, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674802/
https://www.ncbi.nlm.nih.gov/pubmed/26657947
http://dx.doi.org/10.1038/srep18103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674802/
https://www.ncbi.nlm.nih.gov/pubmed/26657947
http://dx.doi.org/10.1038/srep18103

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