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NephroCheck data compared to serum creatinine in various clinical settings

BACKGROUND: Acute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier injury to the most sensitive part of tubular cells located at the proximal tub...

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Autores principales: Pajenda, Sahra, Ilhan-Mutlu, Aysegül, Preusser, Matthias, Roka, Sebastian, Druml, Wilfred, Wagner, Ludwig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674950/
https://www.ncbi.nlm.nih.gov/pubmed/26651477
http://dx.doi.org/10.1186/s12882-015-0203-5
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author Pajenda, Sahra
Ilhan-Mutlu, Aysegül
Preusser, Matthias
Roka, Sebastian
Druml, Wilfred
Wagner, Ludwig
author_facet Pajenda, Sahra
Ilhan-Mutlu, Aysegül
Preusser, Matthias
Roka, Sebastian
Druml, Wilfred
Wagner, Ludwig
author_sort Pajenda, Sahra
collection PubMed
description BACKGROUND: Acute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier injury to the most sensitive part of tubular cells located at the proximal tubule. The aim of the present study was to investigate the course of two cell-cycle arrest urinary biomarkers compared to serum creatinine in four clinical settings: ischemic reperfusion injury, cardiac failure, severe acute kidney injury, and chemotherapy-induced kidney injury. METHODS: A recently developed bedside test known as NephroCheck measures two urinary parameters: insulin-like growth factor binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2). The test is based on a sandwich immunoassay technique. The final test output, labeled AKIRisk, is shown as a numeric result. RESULTS: This report revealed that [IGFBP7] · [TIMP-2] in urine rise rapidly prior to any change in serum creatinine. A unique feature of all four clinical settings is that a rapid decline predicts the recovery of kidney function. Besides, a subclinical kidney injury might be detected by the test. CONCLUSION: This bedside test detects biomarkers of renal injury. A rapid decline in AKIRisk was associated with the restoration of kidney function, whereas a prolonged high AKIRisk score was associated with end-stage renal disease. However, the dynamics seem to differ, depending on the cause and the extent of injury. Further studies will be needed to clarify the issue. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-015-0203-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-46749502015-12-11 NephroCheck data compared to serum creatinine in various clinical settings Pajenda, Sahra Ilhan-Mutlu, Aysegül Preusser, Matthias Roka, Sebastian Druml, Wilfred Wagner, Ludwig BMC Nephrol Research Article BACKGROUND: Acute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier injury to the most sensitive part of tubular cells located at the proximal tubule. The aim of the present study was to investigate the course of two cell-cycle arrest urinary biomarkers compared to serum creatinine in four clinical settings: ischemic reperfusion injury, cardiac failure, severe acute kidney injury, and chemotherapy-induced kidney injury. METHODS: A recently developed bedside test known as NephroCheck measures two urinary parameters: insulin-like growth factor binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2). The test is based on a sandwich immunoassay technique. The final test output, labeled AKIRisk, is shown as a numeric result. RESULTS: This report revealed that [IGFBP7] · [TIMP-2] in urine rise rapidly prior to any change in serum creatinine. A unique feature of all four clinical settings is that a rapid decline predicts the recovery of kidney function. Besides, a subclinical kidney injury might be detected by the test. CONCLUSION: This bedside test detects biomarkers of renal injury. A rapid decline in AKIRisk was associated with the restoration of kidney function, whereas a prolonged high AKIRisk score was associated with end-stage renal disease. However, the dynamics seem to differ, depending on the cause and the extent of injury. Further studies will be needed to clarify the issue. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-015-0203-5) contains supplementary material, which is available to authorized users. BioMed Central 2015-12-09 /pmc/articles/PMC4674950/ /pubmed/26651477 http://dx.doi.org/10.1186/s12882-015-0203-5 Text en © Pajenda et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Pajenda, Sahra
Ilhan-Mutlu, Aysegül
Preusser, Matthias
Roka, Sebastian
Druml, Wilfred
Wagner, Ludwig
NephroCheck data compared to serum creatinine in various clinical settings
title NephroCheck data compared to serum creatinine in various clinical settings
title_full NephroCheck data compared to serum creatinine in various clinical settings
title_fullStr NephroCheck data compared to serum creatinine in various clinical settings
title_full_unstemmed NephroCheck data compared to serum creatinine in various clinical settings
title_short NephroCheck data compared to serum creatinine in various clinical settings
title_sort nephrocheck data compared to serum creatinine in various clinical settings
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674950/
https://www.ncbi.nlm.nih.gov/pubmed/26651477
http://dx.doi.org/10.1186/s12882-015-0203-5
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