Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice

INTRODUCTION: Despite the broad spectrum of antirheumatic drugs, RA is still not well controlled in up to 30-50 % of patients. Inhibition of JAK kinases by means of the pan-JAK inhibitor tofacitinib has demonstrated to be effective even in difficult-to-treat patients. Here, we discuss whether the ef...

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Detalles Bibliográficos
Autores principales: Llop-Guevara, Alba, Porras, Mónica, Cendón, Carla, Di Ceglie, Irene, Siracusa, Francesco, Madarena, Federica, Rinotas, Vagelis, Gómez, Lluís, van Lent, Peter L., Douni, Eleni, Chang, Hyun Dong, Kamradt, Thomas, Román, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675041/
https://www.ncbi.nlm.nih.gov/pubmed/26653844
http://dx.doi.org/10.1186/s13075-015-0866-0

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