Cargando…
Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
Adipose tissue is now considered as an endocrine organ involved in metabolic and inflammatory reactions. Adiponectin, a 244–amino acid peptide hormone, is associated with insulin resistance and carcinogenesis. Curcumin (diferuloylmethane) is the principal curcuminoid of the popular Indian spice, tur...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675518/ https://www.ncbi.nlm.nih.gov/pubmed/26656720 http://dx.doi.org/10.1371/journal.pone.0144462 |
_version_ | 1782405028669030400 |
---|---|
author | Tsai, Jong-Rung Liu, Po-Len Chen, Yung-Hsiang Chou, Shah-Hwa Cheng, Yu-Jen Hwang, Jhi-Jhu Chong, Inn-Wen |
author_facet | Tsai, Jong-Rung Liu, Po-Len Chen, Yung-Hsiang Chou, Shah-Hwa Cheng, Yu-Jen Hwang, Jhi-Jhu Chong, Inn-Wen |
author_sort | Tsai, Jong-Rung |
collection | PubMed |
description | Adipose tissue is now considered as an endocrine organ involved in metabolic and inflammatory reactions. Adiponectin, a 244–amino acid peptide hormone, is associated with insulin resistance and carcinogenesis. Curcumin (diferuloylmethane) is the principal curcuminoid of the popular Indian spice, turmeric. Curcumin possesses antitumor effects, including the inhibition of neovascularization and regulation of cell cycle and apoptosis. However, the effects of adiponectin and curcumin on non-small cell lung cancer (NSCLC) remain unclear. In this study, we evaluated the expression of adiponectin in paired tumors and normal lung tissues from 77 patients with NSCLC using real-time polymerase chain reaction, western blotting, and immunohistochemistry. Kaplan–Meier survival analysis showed that patients with low adiponectin expression ratio (<1) had significantly longer survival time than those with high expression ratio (>1) (p = 0.015). Curcumin inhibited the migratory and invasive ability of A549 cells via the inhibition of adiponectin expression by blocking the adiponectin receptor 1. Curcumin treatment also inhibited the in vivo tumor growth of A549 cells and adiponectin expression. These results suggest that adiponectin can be a prognostic indicator of NSCLC. The effect of curcumin in decreasing the migratory and invasive ability of A549 cells by inhibiting adiponectin expression is probably mediated through NF-κB/MMP pathways. Curcumin could be an important potential adjuvant therapeutic agent for lung cancer in the future. |
format | Online Article Text |
id | pubmed-4675518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46755182015-12-31 Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway Tsai, Jong-Rung Liu, Po-Len Chen, Yung-Hsiang Chou, Shah-Hwa Cheng, Yu-Jen Hwang, Jhi-Jhu Chong, Inn-Wen PLoS One Research Article Adipose tissue is now considered as an endocrine organ involved in metabolic and inflammatory reactions. Adiponectin, a 244–amino acid peptide hormone, is associated with insulin resistance and carcinogenesis. Curcumin (diferuloylmethane) is the principal curcuminoid of the popular Indian spice, turmeric. Curcumin possesses antitumor effects, including the inhibition of neovascularization and regulation of cell cycle and apoptosis. However, the effects of adiponectin and curcumin on non-small cell lung cancer (NSCLC) remain unclear. In this study, we evaluated the expression of adiponectin in paired tumors and normal lung tissues from 77 patients with NSCLC using real-time polymerase chain reaction, western blotting, and immunohistochemistry. Kaplan–Meier survival analysis showed that patients with low adiponectin expression ratio (<1) had significantly longer survival time than those with high expression ratio (>1) (p = 0.015). Curcumin inhibited the migratory and invasive ability of A549 cells via the inhibition of adiponectin expression by blocking the adiponectin receptor 1. Curcumin treatment also inhibited the in vivo tumor growth of A549 cells and adiponectin expression. These results suggest that adiponectin can be a prognostic indicator of NSCLC. The effect of curcumin in decreasing the migratory and invasive ability of A549 cells by inhibiting adiponectin expression is probably mediated through NF-κB/MMP pathways. Curcumin could be an important potential adjuvant therapeutic agent for lung cancer in the future. Public Library of Science 2015-12-10 /pmc/articles/PMC4675518/ /pubmed/26656720 http://dx.doi.org/10.1371/journal.pone.0144462 Text en © 2015 Tsai et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Tsai, Jong-Rung Liu, Po-Len Chen, Yung-Hsiang Chou, Shah-Hwa Cheng, Yu-Jen Hwang, Jhi-Jhu Chong, Inn-Wen Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway |
title | Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway |
title_full | Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway |
title_fullStr | Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway |
title_full_unstemmed | Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway |
title_short | Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway |
title_sort | curcumin inhibits non-small cell lung cancer cells metastasis through the adiponectin/nf-κb/mmps signaling pathway |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675518/ https://www.ncbi.nlm.nih.gov/pubmed/26656720 http://dx.doi.org/10.1371/journal.pone.0144462 |
work_keys_str_mv | AT tsaijongrung curcumininhibitsnonsmallcelllungcancercellsmetastasisthroughtheadiponectinnfkbmmpssignalingpathway AT liupolen curcumininhibitsnonsmallcelllungcancercellsmetastasisthroughtheadiponectinnfkbmmpssignalingpathway AT chenyunghsiang curcumininhibitsnonsmallcelllungcancercellsmetastasisthroughtheadiponectinnfkbmmpssignalingpathway AT choushahhwa curcumininhibitsnonsmallcelllungcancercellsmetastasisthroughtheadiponectinnfkbmmpssignalingpathway AT chengyujen curcumininhibitsnonsmallcelllungcancercellsmetastasisthroughtheadiponectinnfkbmmpssignalingpathway AT hwangjhijhu curcumininhibitsnonsmallcelllungcancercellsmetastasisthroughtheadiponectinnfkbmmpssignalingpathway AT chonginnwen curcumininhibitsnonsmallcelllungcancercellsmetastasisthroughtheadiponectinnfkbmmpssignalingpathway |