Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter

Lateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain...

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Detalles Bibliográficos
Autores principales: Kramer, Richard H., Davenport, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Unsolved Mystery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675548/
https://www.ncbi.nlm.nih.gov/pubmed/26656622
http://dx.doi.org/10.1371/journal.pbio.1002322
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author Kramer, Richard H.
Davenport, Christopher M.
author_facet Kramer, Richard H.
Davenport, Christopher M.
author_sort Kramer, Richard H.
collection PubMed
description Lateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain. GABA, protons, or an ephaptic mechanism have all been suggested as the primary mediator of feedback. However, the complexity of the reciprocal cone to horizontal cell synapse has left the identity of the feedback signal an unsolved mystery.
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spelling pubmed-46755482015-12-31 Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter Kramer, Richard H. Davenport, Christopher M. PLoS Biol Unsolved Mystery Lateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain. GABA, protons, or an ephaptic mechanism have all been suggested as the primary mediator of feedback. However, the complexity of the reciprocal cone to horizontal cell synapse has left the identity of the feedback signal an unsolved mystery. Public Library of Science 2015-12-10 /pmc/articles/PMC4675548/ /pubmed/26656622 http://dx.doi.org/10.1371/journal.pbio.1002322 Text en © 2015 Kramer, Davenport http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Unsolved Mystery
Kramer, Richard H.
Davenport, Christopher M.
Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
title Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
title_full Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
title_fullStr Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
title_full_unstemmed Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
title_short Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
title_sort lateral inhibition in the vertebrate retina: the case of the missing neurotransmitter
topic Unsolved Mystery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675548/
https://www.ncbi.nlm.nih.gov/pubmed/26656622
http://dx.doi.org/10.1371/journal.pbio.1002322
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