β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia

Activation of nuclear β-catenin and expression of its transcriptional targets promotes chronic myeloid leukemia (CML) progression, tyrosine kinase inhibitor (TKI) resistance, and leukemic stem cell self-renewal. We report that nuclear β-catenin plays a role in leukemia cell-intrinsic but not -extrin...

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Detalles Bibliográficos
Autores principales: Eiring, Anna M., Khorashad, Jamshid S., Anderson, David J., Yu, Fan, Redwine, Hannah M., Mason, Clinton C., Reynolds, Kimberly R., Clair, Phillip M., Gantz, Kevin C., Zhang, Tian Y., Pomicter, Anthony D., Kraft, Ira L., Bowler, Amber D., Johnson, Kara, Mac Partlin, Mary, O’Hare, Thomas, Deininger, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675686/
https://www.ncbi.nlm.nih.gov/pubmed/26202934
http://dx.doi.org/10.1038/leu.2015.196

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