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Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience

INTRODUCTION: The aim of this study was to describe peri-procedural antithrombotic use in patients undergoing transcatheter aortic valve replacement (TAVR) at a single academic medical center. METHODS: Retrospective collection of antiplatelet and anticoagulant use during the index hospitalization fo...

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Autores principales: Rossi, Jeffrey E., Noll, Andrew, Bergmark, Brian, McCabe, James M., Nemer, David, Okada, David R., Vasudevan, Anant, Davidson, Michael, Welt, Frederick, Eisenhauer, Andrew, Shah, Pinak, Giugliano, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675746/
https://www.ncbi.nlm.nih.gov/pubmed/26399647
http://dx.doi.org/10.1007/s40119-015-0050-2
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author Rossi, Jeffrey E.
Noll, Andrew
Bergmark, Brian
McCabe, James M.
Nemer, David
Okada, David R.
Vasudevan, Anant
Davidson, Michael
Welt, Frederick
Eisenhauer, Andrew
Shah, Pinak
Giugliano, Robert
author_facet Rossi, Jeffrey E.
Noll, Andrew
Bergmark, Brian
McCabe, James M.
Nemer, David
Okada, David R.
Vasudevan, Anant
Davidson, Michael
Welt, Frederick
Eisenhauer, Andrew
Shah, Pinak
Giugliano, Robert
author_sort Rossi, Jeffrey E.
collection PubMed
description INTRODUCTION: The aim of this study was to describe peri-procedural antithrombotic use in patients undergoing transcatheter aortic valve replacement (TAVR) at a single academic medical center. METHODS: Retrospective collection of antiplatelet and anticoagulant use during the index hospitalization for all patients undergoing TAVR at our institution from April 2009 through March 2014. RESULTS: Of a total of 255 patients undergoing the procedure, 132 (51%) had an indication for anticoagulation pre-TAVR and 92 (70% of those with an indication) were on treatment. On discharge, 106 patients (44% of total surviving to discharge, 73% of those surviving with an indication for anticoagulation) were treated with oral anticoagulation. Of these patients, 89 (84%) were discharged on aspirin and an oral anticoagulant without clopidogrel. Only 122 (51% of total patients) were discharged on the regimen of aspirin and clopidogrel alone. CONCLUSION: Peri-procedural antithrombotic regimens vary greatly following TAVR. More than half of patients have an indication for anticoagulation following the procedure. Most patients at our institution who require anticoagulation are discharged on aspirin and an oral anticoagulant, though the optimal regimen requires further investigation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40119-015-0050-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-46757462015-12-18 Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience Rossi, Jeffrey E. Noll, Andrew Bergmark, Brian McCabe, James M. Nemer, David Okada, David R. Vasudevan, Anant Davidson, Michael Welt, Frederick Eisenhauer, Andrew Shah, Pinak Giugliano, Robert Cardiol Ther Brief Report INTRODUCTION: The aim of this study was to describe peri-procedural antithrombotic use in patients undergoing transcatheter aortic valve replacement (TAVR) at a single academic medical center. METHODS: Retrospective collection of antiplatelet and anticoagulant use during the index hospitalization for all patients undergoing TAVR at our institution from April 2009 through March 2014. RESULTS: Of a total of 255 patients undergoing the procedure, 132 (51%) had an indication for anticoagulation pre-TAVR and 92 (70% of those with an indication) were on treatment. On discharge, 106 patients (44% of total surviving to discharge, 73% of those surviving with an indication for anticoagulation) were treated with oral anticoagulation. Of these patients, 89 (84%) were discharged on aspirin and an oral anticoagulant without clopidogrel. Only 122 (51% of total patients) were discharged on the regimen of aspirin and clopidogrel alone. CONCLUSION: Peri-procedural antithrombotic regimens vary greatly following TAVR. More than half of patients have an indication for anticoagulation following the procedure. Most patients at our institution who require anticoagulation are discharged on aspirin and an oral anticoagulant, though the optimal regimen requires further investigation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40119-015-0050-2) contains supplementary material, which is available to authorized users. Springer Healthcare 2015-09-23 2015-12 /pmc/articles/PMC4675746/ /pubmed/26399647 http://dx.doi.org/10.1007/s40119-015-0050-2 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Brief Report
Rossi, Jeffrey E.
Noll, Andrew
Bergmark, Brian
McCabe, James M.
Nemer, David
Okada, David R.
Vasudevan, Anant
Davidson, Michael
Welt, Frederick
Eisenhauer, Andrew
Shah, Pinak
Giugliano, Robert
Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience
title Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience
title_full Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience
title_fullStr Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience
title_full_unstemmed Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience
title_short Variability in Antithrombotic Therapy Regimens Peri-TAVR: A Single Academic Center Experience
title_sort variability in antithrombotic therapy regimens peri-tavr: a single academic center experience
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675746/
https://www.ncbi.nlm.nih.gov/pubmed/26399647
http://dx.doi.org/10.1007/s40119-015-0050-2
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