Identification of new miRNA biomarkers associated with HER2-positive breast cancers

Human epidermal growth factor receptor 2 (HER2) is overexpressed/amplified in ∼30% breast cancers which are associated with poor prognosis. microRNAs are small non-coding RNA which play an important role in many physiological conditions including cancer. Here we screened and identified many miRNAs w...

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Autores principales: Tashkandi, Hossam, Shah, Nirav, Patel, Yogin, Chen, Hexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675790/
https://www.ncbi.nlm.nih.gov/pubmed/26697527
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author Tashkandi, Hossam
Shah, Nirav
Patel, Yogin
Chen, Hexin
author_facet Tashkandi, Hossam
Shah, Nirav
Patel, Yogin
Chen, Hexin
author_sort Tashkandi, Hossam
collection PubMed
description Human epidermal growth factor receptor 2 (HER2) is overexpressed/amplified in ∼30% breast cancers which are associated with poor prognosis. microRNAs are small non-coding RNA which play an important role in many physiological conditions including cancer. Here we screened and identified many miRNAs which are dysregulated by HER2 overexpression. In line with our quantitative PCR analysis data, in silico analysis of microRNA expression profiles of 1302 breast tumors revealed that miR-146a-5p is up-regulated and miR-181d and miR-195-5p are down-regulated in HER2-positive tumors. Furthermore, the expression levels of these microRNAs can significantly predict patient survival and thus potentially serve as new prognostic markers for HER2-positive breast cancer.
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spelling pubmed-46757902015-12-22 Identification of new miRNA biomarkers associated with HER2-positive breast cancers Tashkandi, Hossam Shah, Nirav Patel, Yogin Chen, Hexin Oncoscience Research Paper Human epidermal growth factor receptor 2 (HER2) is overexpressed/amplified in ∼30% breast cancers which are associated with poor prognosis. microRNAs are small non-coding RNA which play an important role in many physiological conditions including cancer. Here we screened and identified many miRNAs which are dysregulated by HER2 overexpression. In line with our quantitative PCR analysis data, in silico analysis of microRNA expression profiles of 1302 breast tumors revealed that miR-146a-5p is up-regulated and miR-181d and miR-195-5p are down-regulated in HER2-positive tumors. Furthermore, the expression levels of these microRNAs can significantly predict patient survival and thus potentially serve as new prognostic markers for HER2-positive breast cancer. Impact Journals LLC 2015-12-02 /pmc/articles/PMC4675790/ /pubmed/26697527 Text en Copyright: © 2015 Tashkandi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Tashkandi, Hossam
Shah, Nirav
Patel, Yogin
Chen, Hexin
Identification of new miRNA biomarkers associated with HER2-positive breast cancers
title Identification of new miRNA biomarkers associated with HER2-positive breast cancers
title_full Identification of new miRNA biomarkers associated with HER2-positive breast cancers
title_fullStr Identification of new miRNA biomarkers associated with HER2-positive breast cancers
title_full_unstemmed Identification of new miRNA biomarkers associated with HER2-positive breast cancers
title_short Identification of new miRNA biomarkers associated with HER2-positive breast cancers
title_sort identification of new mirna biomarkers associated with her2-positive breast cancers
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675790/
https://www.ncbi.nlm.nih.gov/pubmed/26697527
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AT patelyogin identificationofnewmirnabiomarkersassociatedwithher2positivebreastcancers
AT chenhexin identificationofnewmirnabiomarkersassociatedwithher2positivebreastcancers

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