Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis

Triptolide (TP), a major active component of Tripterygium wilfordii Hook.F. (TWHF), is used to treat rheumatoid arthritis (RA). However, it has a narrow therapeutic window due to its serious toxicities. To increase the therapeutic index, a new triptolide-loaded transdermal delivery system, named tri...

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Detalles Bibliográficos
Autores principales: Chen, Gui, Hao, Baohua, Ju, Dahong, Liu, Meijie, Zhao, Hongyan, Du, Zhongping, Xia, Jizi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675819/
https://www.ncbi.nlm.nih.gov/pubmed/26713272
http://dx.doi.org/10.1016/j.apsb.2015.09.006

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