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Single-cell transcriptome analysis reveals coordinated ectopic gene expression patterns in medullary thymic epithelial cells

Expression of tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for self-tolerance induction and prevents autoimmunity, with each TRA being expressed in only a few mTECs. How this process is regulated in single mTECs and coordinated at the population le...

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Detalles Bibliográficos
Autores principales:	Brennecke, Philip, Reyes, Alejandro, Pinto, Sheena, Rattay, Kristin, Nguyen, Michelle, Küchler, Rita, Huber, Wolfgang, Kyewski, Bruno, Steinmetz, Lars M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675844/ https://www.ncbi.nlm.nih.gov/pubmed/26237553 http://dx.doi.org/10.1038/ni.3246

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