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Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

Multinucleated giant cells (MGCs) form by fusion of macrophages and are presumed to contribute to the removal of debris from tissues. In a systematic in vitro analysis, we show that IL-4-induced MGCs phagocytosed large and complement-opsonized materials more effectively than their unfused M2 macroph...

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Detalles Bibliográficos
Autores principales:	Milde, Ronny, Ritter, Julia, Tennent, Glenys A., Loesch, Andrzej, Martinez, Fernando O., Gordon, Siamon, Pepys, Mark B., Verschoor, Admar, Helming, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675895/ https://www.ncbi.nlm.nih.gov/pubmed/26628365 http://dx.doi.org/10.1016/j.celrep.2015.10.065

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