Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca(2+)-Dependent Manner

BACKGROUND: Phosphorylation state of dopamine- and cAMP-regulated phosphoprotein, molecular weight 32kDa (DARPP32) is crucial to understand drug-mediated synaptic plasticity. In this study, mechanisms underlying repeated cocaine-stimulated phosphorylation of DARPP32 at threonine 75 (pDARPP32-Thr75)...

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Detalles Bibliográficos
Autores principales: Kim, Jieun, Ryu, In Soo, Seo, Su Yeon, Choe, Eun Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675983/
https://www.ncbi.nlm.nih.gov/pubmed/26142455
http://dx.doi.org/10.1093/ijnp/pyv075

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