H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?

Alzheimer's type of neurodegeneration dramatically affects H(2)S and NO synthesis and interactions in the brain, which results in dysregulated vasomotor function, brain tissue hypoperfusion and hypoxia, development of perivascular inflammation, promotion of Aβ deposition, and impairment of neur...

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Autores principales: Salmina, Alla B., Komleva, Yulia K., Szijártó, István A., Gorina, Yana V., Lopatina, Olga L., Gertsog, Galina E., Filipovic, Milos R., Gollasch, Maik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675996/
https://www.ncbi.nlm.nih.gov/pubmed/26696896
http://dx.doi.org/10.3389/fphys.2015.00361
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author Salmina, Alla B.
Komleva, Yulia K.
Szijártó, István A.
Gorina, Yana V.
Lopatina, Olga L.
Gertsog, Galina E.
Filipovic, Milos R.
Gollasch, Maik
author_facet Salmina, Alla B.
Komleva, Yulia K.
Szijártó, István A.
Gorina, Yana V.
Lopatina, Olga L.
Gertsog, Galina E.
Filipovic, Milos R.
Gollasch, Maik
author_sort Salmina, Alla B.
collection PubMed
description Alzheimer's type of neurodegeneration dramatically affects H(2)S and NO synthesis and interactions in the brain, which results in dysregulated vasomotor function, brain tissue hypoperfusion and hypoxia, development of perivascular inflammation, promotion of Aβ deposition, and impairment of neurogenesis/angiogenesis. H(2)S- and NO-signaling pathways have been described to offer protection against Alzheimer's amyloid vasculopathy and neurodegeneration. This review describes recent developments of the increasing relevance of H(2)S and NO in Alzheimer's disease (AD). More studies are however needed to fully determine their potential use as therapeutic targets in Alzheimer's and other forms of vascular dementia.
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spelling pubmed-46759962015-12-22 H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism? Salmina, Alla B. Komleva, Yulia K. Szijártó, István A. Gorina, Yana V. Lopatina, Olga L. Gertsog, Galina E. Filipovic, Milos R. Gollasch, Maik Front Physiol Physiology Alzheimer's type of neurodegeneration dramatically affects H(2)S and NO synthesis and interactions in the brain, which results in dysregulated vasomotor function, brain tissue hypoperfusion and hypoxia, development of perivascular inflammation, promotion of Aβ deposition, and impairment of neurogenesis/angiogenesis. H(2)S- and NO-signaling pathways have been described to offer protection against Alzheimer's amyloid vasculopathy and neurodegeneration. This review describes recent developments of the increasing relevance of H(2)S and NO in Alzheimer's disease (AD). More studies are however needed to fully determine their potential use as therapeutic targets in Alzheimer's and other forms of vascular dementia. Frontiers Media S.A. 2015-12-11 /pmc/articles/PMC4675996/ /pubmed/26696896 http://dx.doi.org/10.3389/fphys.2015.00361 Text en Copyright © 2015 Salmina, Komleva, Szijártó, Gorina, Lopatina, Gertsog, Filipovic and Gollasch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Salmina, Alla B.
Komleva, Yulia K.
Szijártó, István A.
Gorina, Yana V.
Lopatina, Olga L.
Gertsog, Galina E.
Filipovic, Milos R.
Gollasch, Maik
H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
title H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
title_full H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
title_fullStr H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
title_full_unstemmed H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
title_short H(2)S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
title_sort h(2)s- and no-signaling pathways in alzheimer's amyloid vasculopathy: synergism or antagonism?
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675996/
https://www.ncbi.nlm.nih.gov/pubmed/26696896
http://dx.doi.org/10.3389/fphys.2015.00361
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