Effect of Transcranial Direct Current Stimulation on Prefrontal Inhibition in Schizophrenia Patients with Persistent Auditory Hallucinations: A Study on Antisaccade Task Performance

BACKGROUND: Deficient prefrontal cortex inhibitory control is of particular interest with regard to the pathogenesis of auditory hallucinations (AHs) in schizophrenia. Antisaccade task performance is a sensitive index of prefrontal inhibitory function and has been consistently found to be abnormal i...

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Detalles Bibliográficos
Autores principales: Subramaniam, Aditi, Agarwal, Sri Mahavir, Kalmady, Sunil, Shivakumar, Venkataram, Chhabra, Harleen, Bose, Anushree, Damodharan, Dinakaran, Narayanaswamy, Janardhanan C., Hutton, Sam B., Venkatasubramanian, Ganesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676208/
https://www.ncbi.nlm.nih.gov/pubmed/26702174
http://dx.doi.org/10.4103/0253-7176.168584
Descripción
Sumario:BACKGROUND: Deficient prefrontal cortex inhibitory control is of particular interest with regard to the pathogenesis of auditory hallucinations (AHs) in schizophrenia. Antisaccade task performance is a sensitive index of prefrontal inhibitory function and has been consistently found to be abnormal in schizophrenia. METHODS: This study investigated the effect of transcranial direct current stimulation (tDCS) on antisaccade performance in 13 schizophrenia patients. RESULTS: The tDCS resulted in significant reduction in antisaccade error percentage (t = 3.4; P = 0.005), final eye position gain (t = 2.3; P = 0.042), and AHs severity (t = 4.1; P = 0.003). CONCLUSION: Our results raise the possibility that improvement in antisaccade performance and severity of AH may be mechanistically related.

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