The Signature Program: Bringing the Protocol to the Patient

Early‐phase clinical development in oncology has evolved dramatically with the deciphering of the human genome in 2004. Genomic analysis and the tools identifying genetically disrupted pathways within a patient's tumor have been a driving force for personalized medicine and for the development...

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Detalles Bibliográficos
Autores principales: Kang, BP, Slosberg, E, Snodgrass, S, Lebedinsky, C, Berry, DA, Corless, CL, Stein, S, Salvado, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676287/
https://www.ncbi.nlm.nih.gov/pubmed/25810246
http://dx.doi.org/10.1002/cpt.126
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author Kang, BP
Slosberg, E
Snodgrass, S
Lebedinsky, C
Berry, DA
Corless, CL
Stein, S
Salvado, A
author_facet Kang, BP
Slosberg, E
Snodgrass, S
Lebedinsky, C
Berry, DA
Corless, CL
Stein, S
Salvado, A
author_sort Kang, BP
collection PubMed
description Early‐phase clinical development in oncology has evolved dramatically with the deciphering of the human genome in 2004. Genomic analysis and the tools identifying genetically disrupted pathways within a patient's tumor have been a driving force for personalized medicine and for the development of highly targeted novel therapies. Tumors are often genetically heterogeneous, with multiple concurrent genetic abnormalities. On the other hand, tumors arising from different tissues may share identical molecular drivers.
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spelling pubmed-46762872015-12-19 The Signature Program: Bringing the Protocol to the Patient Kang, BP Slosberg, E Snodgrass, S Lebedinsky, C Berry, DA Corless, CL Stein, S Salvado, A Clin Pharmacol Ther Development Early‐phase clinical development in oncology has evolved dramatically with the deciphering of the human genome in 2004. Genomic analysis and the tools identifying genetically disrupted pathways within a patient's tumor have been a driving force for personalized medicine and for the development of highly targeted novel therapies. Tumors are often genetically heterogeneous, with multiple concurrent genetic abnormalities. On the other hand, tumors arising from different tissues may share identical molecular drivers. John Wiley and Sons Inc. 2015-05-11 2015-08 /pmc/articles/PMC4676287/ /pubmed/25810246 http://dx.doi.org/10.1002/cpt.126 Text en © 2015 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of The American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Development
Kang, BP
Slosberg, E
Snodgrass, S
Lebedinsky, C
Berry, DA
Corless, CL
Stein, S
Salvado, A
The Signature Program: Bringing the Protocol to the Patient
title The Signature Program: Bringing the Protocol to the Patient
title_full The Signature Program: Bringing the Protocol to the Patient
title_fullStr The Signature Program: Bringing the Protocol to the Patient
title_full_unstemmed The Signature Program: Bringing the Protocol to the Patient
title_short The Signature Program: Bringing the Protocol to the Patient
title_sort signature program: bringing the protocol to the patient
topic Development
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676287/
https://www.ncbi.nlm.nih.gov/pubmed/25810246
http://dx.doi.org/10.1002/cpt.126
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