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Spatiotemporal ablation of CXCR2 on oligodendrocyte lineage cells: Role in myelin repair

BACKGROUND: Residual CXCR2 expression on CNS cells in Cxcr2(+/−)→Cxcr2(−/−) chimeric animals slowed remyelination after both experimental autoimmune encephalomyelitis and cuprizone-induced demyelination. METHODS: We generated Cxcr2(fl/−):PLPCre-ER(T) mice enabling an inducible, conditional deletion...

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Detalles Bibliográficos
Autores principales:	Liu, LiPing, Spangler, Lisa C., Prager, Briana, Benson, Bryan, Hu, BingQing, Shi, Samuel, Love, Anna, Zhang, CunJin, Yu, Meigen, Cotleur, Anne C., Ransohoff, Richard M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676354/ https://www.ncbi.nlm.nih.gov/pubmed/26668819 http://dx.doi.org/10.1212/NXI.0000000000000174

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