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The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects

RNA interference (RNAi) is a powerful tool for post-transcriptional gene silencing. However, the siRNA guide strand may bind unintended off-target transcripts via partial sequence complementarity by a mechanism closely mirroring micro RNA (miRNA) silencing. To better understand these off-target effe...

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Detalles Bibliográficos
Autores principales:	Kamola, Piotr J., Nakano, Yuko, Takahashi, Tomoko, Wilson, Paul A., Ui-Tei, Kumiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676691/ https://www.ncbi.nlm.nih.gov/pubmed/26657993 http://dx.doi.org/10.1371/journal.pcbi.1004656

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