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Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment

Increasing evidences suggested the association between leptin and cognitive functions. Estrogen is an important factor that regulates the production and metabolism of leptin. However, little is known about the relationship between leptin and estrogen in mild cognitive impairment (MCI). Plasma levels...

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Autores principales: Xing, Yi, Liu, Jianghong, Xu, Jingdong, Yin, Linlin, Wang, Lin, Li, Junjie, Yu, Zhipeng, Li, Fangyu, Gao, Ran, Jia, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677007/
https://www.ncbi.nlm.nih.gov/pubmed/26693203
http://dx.doi.org/10.1155/2015/450237
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author Xing, Yi
Liu, Jianghong
Xu, Jingdong
Yin, Linlin
Wang, Lin
Li, Junjie
Yu, Zhipeng
Li, Fangyu
Gao, Ran
Jia, Jianping
author_facet Xing, Yi
Liu, Jianghong
Xu, Jingdong
Yin, Linlin
Wang, Lin
Li, Junjie
Yu, Zhipeng
Li, Fangyu
Gao, Ran
Jia, Jianping
author_sort Xing, Yi
collection PubMed
description Increasing evidences suggested the association between leptin and cognitive functions. Estrogen is an important factor that regulates the production and metabolism of leptin. However, little is known about the relationship between leptin and estrogen in mild cognitive impairment (MCI). Plasma levels of leptin, total estradiol, and β-amyloid protein (Aβ) were measured in a total of 23 female amnestic MCI (aMCI) patients and 19 female cognitively normal controls. This study showed that female aMCI patients had lower plasma levels of leptin and higher levels of estradiol compared to female normal controls. Leptin and estradiol levels were not correlated with cognitive performances or plasma Aβ levels in either aMCI patients or normal controls. There was a significant negative correlation between leptin and estrogen in female aMCI patients (r = −0.633, p = 0.002) but not in female normal controls. The potential mechanisms of this disease-stage-specific association between leptin and estrogen need further investigations.
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spelling pubmed-46770072015-12-21 Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment Xing, Yi Liu, Jianghong Xu, Jingdong Yin, Linlin Wang, Lin Li, Junjie Yu, Zhipeng Li, Fangyu Gao, Ran Jia, Jianping Dis Markers Research Article Increasing evidences suggested the association between leptin and cognitive functions. Estrogen is an important factor that regulates the production and metabolism of leptin. However, little is known about the relationship between leptin and estrogen in mild cognitive impairment (MCI). Plasma levels of leptin, total estradiol, and β-amyloid protein (Aβ) were measured in a total of 23 female amnestic MCI (aMCI) patients and 19 female cognitively normal controls. This study showed that female aMCI patients had lower plasma levels of leptin and higher levels of estradiol compared to female normal controls. Leptin and estradiol levels were not correlated with cognitive performances or plasma Aβ levels in either aMCI patients or normal controls. There was a significant negative correlation between leptin and estrogen in female aMCI patients (r = −0.633, p = 0.002) but not in female normal controls. The potential mechanisms of this disease-stage-specific association between leptin and estrogen need further investigations. Hindawi Publishing Corporation 2015 2015-11-29 /pmc/articles/PMC4677007/ /pubmed/26693203 http://dx.doi.org/10.1155/2015/450237 Text en Copyright © 2015 Yi Xing et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xing, Yi
Liu, Jianghong
Xu, Jingdong
Yin, Linlin
Wang, Lin
Li, Junjie
Yu, Zhipeng
Li, Fangyu
Gao, Ran
Jia, Jianping
Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment
title Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment
title_full Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment
title_fullStr Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment
title_full_unstemmed Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment
title_short Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment
title_sort association between plasma leptin and estrogen in female patients of amnestic mild cognitive impairment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677007/
https://www.ncbi.nlm.nih.gov/pubmed/26693203
http://dx.doi.org/10.1155/2015/450237
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