Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis

Pegaspargase is used to treat acute lymphocytic leukemia (ALL). Pegaspargase definitely has its benefits in treating ALL; however we cannot lose sight of one of its very rare but potentially deadly complications, acute pancreatitis. Clinicians should monitor triglycerides while the patient is on tre...

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Autores principales: Vyas, Neil, Ching Companioni, Rafael, Tiba, Melik, Alkhawam, Hassan, Walfish, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677038/
https://www.ncbi.nlm.nih.gov/pubmed/26693361
http://dx.doi.org/10.1155/2015/753062
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author Vyas, Neil
Ching Companioni, Rafael
Tiba, Melik
Alkhawam, Hassan
Walfish, Aaron
author_facet Vyas, Neil
Ching Companioni, Rafael
Tiba, Melik
Alkhawam, Hassan
Walfish, Aaron
author_sort Vyas, Neil
collection PubMed
description Pegaspargase is used to treat acute lymphocytic leukemia (ALL). Pegaspargase definitely has its benefits in treating ALL; however we cannot lose sight of one of its very rare but potentially deadly complications, acute pancreatitis. Clinicians should monitor triglycerides while the patient is on treatment with Pegaspargase and suspect acute pancreatitis if the patient develops abdominal pain. If pancreatitis occurs, therapy should be stopped immediately and not reinstituted. For patients with hypertriglyceridemia without pancreatitis, discontinuation of therapy should be considered.
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spelling pubmed-46770382015-12-21 Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis Vyas, Neil Ching Companioni, Rafael Tiba, Melik Alkhawam, Hassan Walfish, Aaron Case Rep Gastrointest Med Case Report Pegaspargase is used to treat acute lymphocytic leukemia (ALL). Pegaspargase definitely has its benefits in treating ALL; however we cannot lose sight of one of its very rare but potentially deadly complications, acute pancreatitis. Clinicians should monitor triglycerides while the patient is on treatment with Pegaspargase and suspect acute pancreatitis if the patient develops abdominal pain. If pancreatitis occurs, therapy should be stopped immediately and not reinstituted. For patients with hypertriglyceridemia without pancreatitis, discontinuation of therapy should be considered. Hindawi Publishing Corporation 2015 2015-11-29 /pmc/articles/PMC4677038/ /pubmed/26693361 http://dx.doi.org/10.1155/2015/753062 Text en Copyright © 2015 Neil Vyas et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Vyas, Neil
Ching Companioni, Rafael
Tiba, Melik
Alkhawam, Hassan
Walfish, Aaron
Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis
title Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis
title_full Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis
title_fullStr Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis
title_full_unstemmed Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis
title_short Pegaspargase Induced Hypertriglyceridemia Resulting in Severe Fatal Pancreatitis
title_sort pegaspargase induced hypertriglyceridemia resulting in severe fatal pancreatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677038/
https://www.ncbi.nlm.nih.gov/pubmed/26693361
http://dx.doi.org/10.1155/2015/753062
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