Simvastatin suppresses breast cancer cell proliferation induced by senescent cells

Cellular senescence suppresses cancer by preventing the proliferation of damaged cells, but senescent cells can also promote cancer though the pro-inflammatory senescence-associated secretory phenotype (SASP). Simvastatin, an HMG-coA reductase inhibitor, is known to attenuate inflammation and preven...

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Detalles Bibliográficos
Autores principales: Liu, Su, Uppal, Harpreet, Demaria, Marco, Desprez, Pierre-Yves, Campisi, Judith, Kapahi, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677323/
https://www.ncbi.nlm.nih.gov/pubmed/26658759
http://dx.doi.org/10.1038/srep17895

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