Cargando…

The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort

BACKGROUND: A polyspecific, intrathecal humoral immune response against the neurotropic viruses, measles, rubella and varicella zoster virus, called “MRZ reaction” (MRZR), is present in the majority of patients with multiple sclerosis (MS). Neurosarcoidosis (NS) and acute disseminated encephalomyeli...

Descripción completa

Detalles Bibliográficos
Autores principales: Hottenrott, Tilman, Dersch, Rick, Berger, Benjamin, Rauer, Sebastian, Eckenweiler, Matthias, Huzly, Daniela, Stich, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677451/
https://www.ncbi.nlm.nih.gov/pubmed/26652013
http://dx.doi.org/10.1186/s12987-015-0024-8
_version_ 1782405331147554816
author Hottenrott, Tilman
Dersch, Rick
Berger, Benjamin
Rauer, Sebastian
Eckenweiler, Matthias
Huzly, Daniela
Stich, Oliver
author_facet Hottenrott, Tilman
Dersch, Rick
Berger, Benjamin
Rauer, Sebastian
Eckenweiler, Matthias
Huzly, Daniela
Stich, Oliver
author_sort Hottenrott, Tilman
collection PubMed
description BACKGROUND: A polyspecific, intrathecal humoral immune response against the neurotropic viruses, measles, rubella and varicella zoster virus, called “MRZ reaction” (MRZR), is present in the majority of patients with multiple sclerosis (MS). Neurosarcoidosis (NS) and acute disseminated encephalomyelitis (ADEM) are important clinical differential diagnoses of MS. Autoimmune encephalitis (AIE) represents a well characterized autoimmune CNS disorder with intrathecal antibody synthesis. The aim of this study was to investigate the specificity of MRZR for MS in patients with NS, ADEM and AIE for the first time, and to compare it with the diagnostic value of oligoclonal bands (OCB). PATIENTS AND METHODS: Twenty-two patients with NS, 17 with AIE, 8 with ADEM and 33 with MS serving as controls were analyzed for OCB and MRZR by calculation of the antibody index (AI) for each virus. MRZR was considered as positive if at least two AIs were ≥1.5. RESULTS: A positive MRZR was statistically significantly less frequent in NS (9 %), AIE (11 %) and ADEM (0 %) compared to MS patients (70 %; p < 0.001 each). The specificity of MRZR for MS was 92 % in the study cohort. In comparison to MRZR, the OCB showed a higher sensitivity (100 %), but a lower specificity (69 %) for MS. CONCLUSION: These results indicate that MRZR seems to be the most specific available CSF marker of MS.
format Online
Article
Text
id pubmed-4677451
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-46774512015-12-15 The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort Hottenrott, Tilman Dersch, Rick Berger, Benjamin Rauer, Sebastian Eckenweiler, Matthias Huzly, Daniela Stich, Oliver Fluids Barriers CNS Research BACKGROUND: A polyspecific, intrathecal humoral immune response against the neurotropic viruses, measles, rubella and varicella zoster virus, called “MRZ reaction” (MRZR), is present in the majority of patients with multiple sclerosis (MS). Neurosarcoidosis (NS) and acute disseminated encephalomyelitis (ADEM) are important clinical differential diagnoses of MS. Autoimmune encephalitis (AIE) represents a well characterized autoimmune CNS disorder with intrathecal antibody synthesis. The aim of this study was to investigate the specificity of MRZR for MS in patients with NS, ADEM and AIE for the first time, and to compare it with the diagnostic value of oligoclonal bands (OCB). PATIENTS AND METHODS: Twenty-two patients with NS, 17 with AIE, 8 with ADEM and 33 with MS serving as controls were analyzed for OCB and MRZR by calculation of the antibody index (AI) for each virus. MRZR was considered as positive if at least two AIs were ≥1.5. RESULTS: A positive MRZR was statistically significantly less frequent in NS (9 %), AIE (11 %) and ADEM (0 %) compared to MS patients (70 %; p < 0.001 each). The specificity of MRZR for MS was 92 % in the study cohort. In comparison to MRZR, the OCB showed a higher sensitivity (100 %), but a lower specificity (69 %) for MS. CONCLUSION: These results indicate that MRZR seems to be the most specific available CSF marker of MS. BioMed Central 2015-12-13 /pmc/articles/PMC4677451/ /pubmed/26652013 http://dx.doi.org/10.1186/s12987-015-0024-8 Text en © Hottenrott et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Hottenrott, Tilman
Dersch, Rick
Berger, Benjamin
Rauer, Sebastian
Eckenweiler, Matthias
Huzly, Daniela
Stich, Oliver
The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort
title The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort
title_full The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort
title_fullStr The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort
title_full_unstemmed The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort
title_short The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort
title_sort intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677451/
https://www.ncbi.nlm.nih.gov/pubmed/26652013
http://dx.doi.org/10.1186/s12987-015-0024-8
work_keys_str_mv AT hottenrotttilman theintrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT derschrick theintrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT bergerbenjamin theintrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT rauersebastian theintrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT eckenweilermatthias theintrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT huzlydaniela theintrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT sticholiver theintrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT hottenrotttilman intrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT derschrick intrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT bergerbenjamin intrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT rauersebastian intrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT eckenweilermatthias intrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT huzlydaniela intrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort
AT sticholiver intrathecalpolyspecificantiviralimmuneresponseinneurosarcoidosisacutedisseminatedencephalomyelitisandautoimmuneencephalitiscomparedtomultiplesclerosisinatertiaryhospitalcohort