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Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children

The incidence of enterovirus D68 (EV-D68) and the spectrum of clinical disease in children are not well known in European countries. We have designed a study with the objective of describing the clinical impact of EV-D68 detected in children with respiratory tract infections. METHODS: As a part of a...

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Autores principales: Calvo, Cristina, Cuevas, María Teresa, Pozo, Francisco, García-García, María Luz, Molinero, Mar, Calderón, Ana, Gonzalez-Esguevillas, Mónica, Pérez-Sautu, Unai, Casas, Inmaculada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677598/
https://www.ncbi.nlm.nih.gov/pubmed/26741582
http://dx.doi.org/10.1097/INF.0000000000000908
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author Calvo, Cristina
Cuevas, María Teresa
Pozo, Francisco
García-García, María Luz
Molinero, Mar
Calderón, Ana
Gonzalez-Esguevillas, Mónica
Pérez-Sautu, Unai
Casas, Inmaculada
author_facet Calvo, Cristina
Cuevas, María Teresa
Pozo, Francisco
García-García, María Luz
Molinero, Mar
Calderón, Ana
Gonzalez-Esguevillas, Mónica
Pérez-Sautu, Unai
Casas, Inmaculada
author_sort Calvo, Cristina
collection PubMed
description The incidence of enterovirus D68 (EV-D68) and the spectrum of clinical disease in children are not well known in European countries. We have designed a study with the objective of describing the clinical impact of EV-D68 detected in children with respiratory tract infections. METHODS: As a part of a prospective study to identify the etiology and clinical characteristics of viral respiratory infections in children in Spain, we performed the analysis of the cases of EV infections in all children hospitalized in a secondary hospital in Madrid, during the epidemic respiratory season 2012–2013. A second group of samples was corresponded to infants of the same area, with ambulatory respiratory infection or asymptomatic. Phylogenetic EV-D68 analysis was made using the viral protein 1 gene (VP1). Clinical data of EV-D68 patients were compared with those infected by rhinovirus in the same period and population. RESULTS: The study population consisted of 720 patients corresponding to 399 episodes of hospitalization for respiratory causes, 44 episodes of ambulatory respiratory infections and 277 children determined as a healthy control group. A total of 22 patients were positive for EVs (3.05%), and 12 of them were specifically typed as EV-D68 (11/443 respiratory infections, 2.5%). The most frequent diagnosis in the 10 hospitalized children with EV-D68 detection was recurrent wheezing. Hypoxia was present in 70% of cases, but admission in the intensive care unit was not required. No neurological signs or symptoms were observed. One patient had an ambulatory mild bronchiolitis and another was asymptomatic. No differences were found with rhinovirus infections except less duration of hypoxia and fever in EV-D68 group. CONCLUSIONS: EV-D68 infections were detected in 3.05% of respiratory studied samples (2.5% of admissions). The infection was associated with wheezing episodes with hypoxia. No admissions to intensive care unit or neurological symptoms were found.
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spelling pubmed-46775982015-12-21 Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children Calvo, Cristina Cuevas, María Teresa Pozo, Francisco García-García, María Luz Molinero, Mar Calderón, Ana Gonzalez-Esguevillas, Mónica Pérez-Sautu, Unai Casas, Inmaculada Pediatr Infect Dis J Original Studies The incidence of enterovirus D68 (EV-D68) and the spectrum of clinical disease in children are not well known in European countries. We have designed a study with the objective of describing the clinical impact of EV-D68 detected in children with respiratory tract infections. METHODS: As a part of a prospective study to identify the etiology and clinical characteristics of viral respiratory infections in children in Spain, we performed the analysis of the cases of EV infections in all children hospitalized in a secondary hospital in Madrid, during the epidemic respiratory season 2012–2013. A second group of samples was corresponded to infants of the same area, with ambulatory respiratory infection or asymptomatic. Phylogenetic EV-D68 analysis was made using the viral protein 1 gene (VP1). Clinical data of EV-D68 patients were compared with those infected by rhinovirus in the same period and population. RESULTS: The study population consisted of 720 patients corresponding to 399 episodes of hospitalization for respiratory causes, 44 episodes of ambulatory respiratory infections and 277 children determined as a healthy control group. A total of 22 patients were positive for EVs (3.05%), and 12 of them were specifically typed as EV-D68 (11/443 respiratory infections, 2.5%). The most frequent diagnosis in the 10 hospitalized children with EV-D68 detection was recurrent wheezing. Hypoxia was present in 70% of cases, but admission in the intensive care unit was not required. No neurological signs or symptoms were observed. One patient had an ambulatory mild bronchiolitis and another was asymptomatic. No differences were found with rhinovirus infections except less duration of hypoxia and fever in EV-D68 group. CONCLUSIONS: EV-D68 infections were detected in 3.05% of respiratory studied samples (2.5% of admissions). The infection was associated with wheezing episodes with hypoxia. No admissions to intensive care unit or neurological symptoms were found. Williams & Wilkins 2016-01 2015-12-11 /pmc/articles/PMC4677598/ /pubmed/26741582 http://dx.doi.org/10.1097/INF.0000000000000908 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Original Studies
Calvo, Cristina
Cuevas, María Teresa
Pozo, Francisco
García-García, María Luz
Molinero, Mar
Calderón, Ana
Gonzalez-Esguevillas, Mónica
Pérez-Sautu, Unai
Casas, Inmaculada
Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children
title Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children
title_full Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children
title_fullStr Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children
title_full_unstemmed Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children
title_short Respiratory Infections by Enterovirus D68 in Outpatients and Inpatients Spanish Children
title_sort respiratory infections by enterovirus d68 in outpatients and inpatients spanish children
topic Original Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677598/
https://www.ncbi.nlm.nih.gov/pubmed/26741582
http://dx.doi.org/10.1097/INF.0000000000000908
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