SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

[Image: see text] We previously discovered compounds based on a 5-aminopyrazole-4-carboxamide scaffold to be potent and selective inhibitors of CDPK1 from T. gondii. The current work, through structure–activity relationship studies, led to the discovery of compounds (34 and 35) with improved charact...

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Autores principales: Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., Fan, Erkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677665/
https://www.ncbi.nlm.nih.gov/pubmed/26693272
http://dx.doi.org/10.1021/acsmedchemlett.5b00319

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