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Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis
PURPOSE: The aim of this study was to examine sequential changes in perivascular granulomatous lesions with acute retinal necrosis (ARN). METHODS: A healthy 46-year-old Japanese woman, who developed floaters and pain in her left eye, underwent optical coherence tomography (OCT), fluorescein angiogra...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677696/ https://www.ncbi.nlm.nih.gov/pubmed/26668578 http://dx.doi.org/10.1159/000442084 |
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author | Sogawa, Takahiro Hashida, Noriyasu Sawa, Miki Nishida, Kohji |
author_facet | Sogawa, Takahiro Hashida, Noriyasu Sawa, Miki Nishida, Kohji |
author_sort | Sogawa, Takahiro |
collection | PubMed |
description | PURPOSE: The aim of this study was to examine sequential changes in perivascular granulomatous lesions with acute retinal necrosis (ARN). METHODS: A healthy 46-year-old Japanese woman, who developed floaters and pain in her left eye, underwent optical coherence tomography (OCT), fluorescein angiography, and routine ophthalmological examinations. Treatment-associated changes in perivascular granulomatous lesions were monitored using spectral-domain (SD)-OCT. RESULTS: The patient had no previous ophthalmic history, and her general condition was good. A slit-lamp examination revealed keratic precipitates and aqueous cells (2+) in the left eye. A fundus examination showed yellow-white patches of necrotizing retinal lesions in the temporal upper area, retinal arteritis, retinal hemorrhage, and vitreous opacities. The patient was diagnosed with ARN according to diagnostic criteria. SD-OCT images confirmed high-intensity and uniform granulomatous deposits in the perivascular area and fovea. Systemic corticosteroids and antiviral therapy were initiated, resulting in the gradual resolution of granulomatous lesions. The patient continues to be followed untreated without evidence of recurrence, retinal detachment, or active inflammation. CONCLUSIONS: This is the first report of perivascular granulomatous lesions in a patient with ARN. Our results showed that the formation of granulomas may be induced in the retina of ARN patients without fulminant inflammation. |
format | Online Article Text |
id | pubmed-4677696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-46776962015-12-14 Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis Sogawa, Takahiro Hashida, Noriyasu Sawa, Miki Nishida, Kohji Case Rep Ophthalmol Published online: November, 2015 PURPOSE: The aim of this study was to examine sequential changes in perivascular granulomatous lesions with acute retinal necrosis (ARN). METHODS: A healthy 46-year-old Japanese woman, who developed floaters and pain in her left eye, underwent optical coherence tomography (OCT), fluorescein angiography, and routine ophthalmological examinations. Treatment-associated changes in perivascular granulomatous lesions were monitored using spectral-domain (SD)-OCT. RESULTS: The patient had no previous ophthalmic history, and her general condition was good. A slit-lamp examination revealed keratic precipitates and aqueous cells (2+) in the left eye. A fundus examination showed yellow-white patches of necrotizing retinal lesions in the temporal upper area, retinal arteritis, retinal hemorrhage, and vitreous opacities. The patient was diagnosed with ARN according to diagnostic criteria. SD-OCT images confirmed high-intensity and uniform granulomatous deposits in the perivascular area and fovea. Systemic corticosteroids and antiviral therapy were initiated, resulting in the gradual resolution of granulomatous lesions. The patient continues to be followed untreated without evidence of recurrence, retinal detachment, or active inflammation. CONCLUSIONS: This is the first report of perivascular granulomatous lesions in a patient with ARN. Our results showed that the formation of granulomas may be induced in the retina of ARN patients without fulminant inflammation. S. Karger AG 2015-11-21 /pmc/articles/PMC4677696/ /pubmed/26668578 http://dx.doi.org/10.1159/000442084 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Published online: November, 2015 Sogawa, Takahiro Hashida, Noriyasu Sawa, Miki Nishida, Kohji Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis |
title | Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis |
title_full | Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis |
title_fullStr | Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis |
title_full_unstemmed | Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis |
title_short | Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis |
title_sort | rare association of perivascular granulomatous lesions in a patient with acute retinal necrosis |
topic | Published online: November, 2015 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677696/ https://www.ncbi.nlm.nih.gov/pubmed/26668578 http://dx.doi.org/10.1159/000442084 |
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