Cargando…

Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis

PURPOSE: The aim of this study was to examine sequential changes in perivascular granulomatous lesions with acute retinal necrosis (ARN). METHODS: A healthy 46-year-old Japanese woman, who developed floaters and pain in her left eye, underwent optical coherence tomography (OCT), fluorescein angiogra...

Descripción completa

Detalles Bibliográficos
Autores principales: Sogawa, Takahiro, Hashida, Noriyasu, Sawa, Miki, Nishida, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677696/
https://www.ncbi.nlm.nih.gov/pubmed/26668578
http://dx.doi.org/10.1159/000442084
_version_ 1782405357358809088
author Sogawa, Takahiro
Hashida, Noriyasu
Sawa, Miki
Nishida, Kohji
author_facet Sogawa, Takahiro
Hashida, Noriyasu
Sawa, Miki
Nishida, Kohji
author_sort Sogawa, Takahiro
collection PubMed
description PURPOSE: The aim of this study was to examine sequential changes in perivascular granulomatous lesions with acute retinal necrosis (ARN). METHODS: A healthy 46-year-old Japanese woman, who developed floaters and pain in her left eye, underwent optical coherence tomography (OCT), fluorescein angiography, and routine ophthalmological examinations. Treatment-associated changes in perivascular granulomatous lesions were monitored using spectral-domain (SD)-OCT. RESULTS: The patient had no previous ophthalmic history, and her general condition was good. A slit-lamp examination revealed keratic precipitates and aqueous cells (2+) in the left eye. A fundus examination showed yellow-white patches of necrotizing retinal lesions in the temporal upper area, retinal arteritis, retinal hemorrhage, and vitreous opacities. The patient was diagnosed with ARN according to diagnostic criteria. SD-OCT images confirmed high-intensity and uniform granulomatous deposits in the perivascular area and fovea. Systemic corticosteroids and antiviral therapy were initiated, resulting in the gradual resolution of granulomatous lesions. The patient continues to be followed untreated without evidence of recurrence, retinal detachment, or active inflammation. CONCLUSIONS: This is the first report of perivascular granulomatous lesions in a patient with ARN. Our results showed that the formation of granulomas may be induced in the retina of ARN patients without fulminant inflammation.
format Online
Article
Text
id pubmed-4677696
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-46776962015-12-14 Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis Sogawa, Takahiro Hashida, Noriyasu Sawa, Miki Nishida, Kohji Case Rep Ophthalmol Published online: November, 2015 PURPOSE: The aim of this study was to examine sequential changes in perivascular granulomatous lesions with acute retinal necrosis (ARN). METHODS: A healthy 46-year-old Japanese woman, who developed floaters and pain in her left eye, underwent optical coherence tomography (OCT), fluorescein angiography, and routine ophthalmological examinations. Treatment-associated changes in perivascular granulomatous lesions were monitored using spectral-domain (SD)-OCT. RESULTS: The patient had no previous ophthalmic history, and her general condition was good. A slit-lamp examination revealed keratic precipitates and aqueous cells (2+) in the left eye. A fundus examination showed yellow-white patches of necrotizing retinal lesions in the temporal upper area, retinal arteritis, retinal hemorrhage, and vitreous opacities. The patient was diagnosed with ARN according to diagnostic criteria. SD-OCT images confirmed high-intensity and uniform granulomatous deposits in the perivascular area and fovea. Systemic corticosteroids and antiviral therapy were initiated, resulting in the gradual resolution of granulomatous lesions. The patient continues to be followed untreated without evidence of recurrence, retinal detachment, or active inflammation. CONCLUSIONS: This is the first report of perivascular granulomatous lesions in a patient with ARN. Our results showed that the formation of granulomas may be induced in the retina of ARN patients without fulminant inflammation. S. Karger AG 2015-11-21 /pmc/articles/PMC4677696/ /pubmed/26668578 http://dx.doi.org/10.1159/000442084 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Published online: November, 2015
Sogawa, Takahiro
Hashida, Noriyasu
Sawa, Miki
Nishida, Kohji
Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis
title Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis
title_full Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis
title_fullStr Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis
title_full_unstemmed Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis
title_short Rare Association of Perivascular Granulomatous Lesions in a Patient with Acute Retinal Necrosis
title_sort rare association of perivascular granulomatous lesions in a patient with acute retinal necrosis
topic Published online: November, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677696/
https://www.ncbi.nlm.nih.gov/pubmed/26668578
http://dx.doi.org/10.1159/000442084
work_keys_str_mv AT sogawatakahiro rareassociationofperivasculargranulomatouslesionsinapatientwithacuteretinalnecrosis
AT hashidanoriyasu rareassociationofperivasculargranulomatouslesionsinapatientwithacuteretinalnecrosis
AT sawamiki rareassociationofperivasculargranulomatouslesionsinapatientwithacuteretinalnecrosis
AT nishidakohji rareassociationofperivasculargranulomatouslesionsinapatientwithacuteretinalnecrosis