Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1

Inhibition of the nucleotide pool sanitizing enzyme MTH1 causes extensive oxidative DNA damages and apoptosis in cancer cells and hence may be used as an anticancer strategy. As natural products have been a rich source of medicinal chemicals, in the present study, we used the MTH1-catalyzed enzymati...

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Detalles Bibliográficos
Autores principales: Dong, Liwei, Wang, Hongge, Niu, Jiajing, Zou, Mingwei, Wu, Nuoting, Yu, Debin, Wang, Ye, Zou, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677763/
https://www.ncbi.nlm.nih.gov/pubmed/26677335
http://dx.doi.org/10.2147/OTT.S94513

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