miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review

Pancreatic ductal adenocarcinoma (PDAC), a rare but lethal tumor, is difficult to diagnose without performing an invasive procedure. miRNAs are known to be deregulated in PDAC patients, and recent studies have shown that they can be used as diagnostic and prognostic of the disease. The detection of...

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Detalles Bibliográficos
Autores principales: Alemar, Bárbara, Gregório, Cleandra, Ashton-Prolla, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677802/
https://www.ncbi.nlm.nih.gov/pubmed/26688661
http://dx.doi.org/10.4137/BMI.S27679
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author Alemar, Bárbara
Gregório, Cleandra
Ashton-Prolla, Patricia
author_facet Alemar, Bárbara
Gregório, Cleandra
Ashton-Prolla, Patricia
author_sort Alemar, Bárbara
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC), a rare but lethal tumor, is difficult to diagnose without performing an invasive procedure. miRNAs are known to be deregulated in PDAC patients, and recent studies have shown that they can be used as diagnostic and prognostic of the disease. The detection of miRNAs in samples acquired through minimally or noninvasive procedures, such as serum, plasma, and saliva, can have a positive impact on the clinical management of these patients. This article is a comprehensive review of the major studies that have evaluated the expression of miRNAs as biomarkers in pancreatic cancer and its premalignant lesions.
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spelling pubmed-46778022015-12-19 miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review Alemar, Bárbara Gregório, Cleandra Ashton-Prolla, Patricia Biomark Insights Review Pancreatic ductal adenocarcinoma (PDAC), a rare but lethal tumor, is difficult to diagnose without performing an invasive procedure. miRNAs are known to be deregulated in PDAC patients, and recent studies have shown that they can be used as diagnostic and prognostic of the disease. The detection of miRNAs in samples acquired through minimally or noninvasive procedures, such as serum, plasma, and saliva, can have a positive impact on the clinical management of these patients. This article is a comprehensive review of the major studies that have evaluated the expression of miRNAs as biomarkers in pancreatic cancer and its premalignant lesions. Libertas Academica 2015-12-13 /pmc/articles/PMC4677802/ /pubmed/26688661 http://dx.doi.org/10.4137/BMI.S27679 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 license.
spellingShingle Review
Alemar, Bárbara
Gregório, Cleandra
Ashton-Prolla, Patricia
miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
title miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
title_full miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
title_fullStr miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
title_full_unstemmed miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
title_short miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
title_sort mirnas as diagnostic and prognostic biomarkers in pancreatic ductal adenocarcinoma and its precursor lesions: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677802/
https://www.ncbi.nlm.nih.gov/pubmed/26688661
http://dx.doi.org/10.4137/BMI.S27679
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