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Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population

Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. We have shown that Pklr deficiency in mice reduces the severity (reduced parasitemia, increased survival) of blood stage malaria induced by infection with Plasmodium chabaudi AS. Likewise,...

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Detalles Bibliográficos
Autores principales:	van Bruggen, Rebekah, Gualtieri, Christian, Iliescu, Alexandra, Louicharoen Cheepsunthorn, Chalisa, Mungkalasut, Punchalee, Trape, Jean-François, Modiano, David, Sodiomon Sirima, Bienvenu, Singhasivanon, Pratap, Lathrop, Mark, Sakuntabhai, Anavaj, Bureau, Jean-François, Gros, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677815/ https://www.ncbi.nlm.nih.gov/pubmed/26658699 http://dx.doi.org/10.1371/journal.pone.0144555

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