Cargando…

Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele

Oxidative stress plays an important part in amnestic mild cognitive impairment (aMCI), the prodromal phase of Alzheimer's disease (AD). Recent evidence shows that polymorphisms in the SOD2 gene affect the elimination of the reactive oxygen species (ROS) generated in mitochondria. The aim of thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gamarra, David, Elcoroaristizabal, Xabier, Fernández-Martínez, Manuel, de Pancorbo, Marian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678069/
https://www.ncbi.nlm.nih.gov/pubmed/26696693
http://dx.doi.org/10.1155/2015/746329
_version_ 1782405387533680640
author Gamarra, David
Elcoroaristizabal, Xabier
Fernández-Martínez, Manuel
de Pancorbo, Marian M.
author_facet Gamarra, David
Elcoroaristizabal, Xabier
Fernández-Martínez, Manuel
de Pancorbo, Marian M.
author_sort Gamarra, David
collection PubMed
description Oxidative stress plays an important part in amnestic mild cognitive impairment (aMCI), the prodromal phase of Alzheimer's disease (AD). Recent evidence shows that polymorphisms in the SOD2 gene affect the elimination of the reactive oxygen species (ROS) generated in mitochondria. The aim of this study was to determine whether the functional rs4880 SNP in the SOD2 gene is a risk factor associated with aMCI and sporadic AD. 216 subjects with aMCI, 355 with AD, and 245 controls have been studied. The SNP rs4880 of the SOD2 gene was genotyped by RT-PCR and the APOE genotype was determined by PCR and RFLPs. Different multinomial logistic regression models were used to determine the risk levels for aMCI and AD. Although the T allele of the SOD2 rs4880 SNP gene (rs4880-T) is not an independent risk for aMCI or AD, this allele increases the risk to aMCI patients carrying at least one APOEε4 allele. Moreover, rs4880-T allele and APOEε4 allele combination has been found to produce an increased risk for AD compared to aMCI reference patients. These results suggest that APOEε4 and rs4880-T genotype may be a risk for aMCI and a predictor of progression from aMCI to AD.
format Online
Article
Text
id pubmed-4678069
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-46780692015-12-22 Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele Gamarra, David Elcoroaristizabal, Xabier Fernández-Martínez, Manuel de Pancorbo, Marian M. Dis Markers Research Article Oxidative stress plays an important part in amnestic mild cognitive impairment (aMCI), the prodromal phase of Alzheimer's disease (AD). Recent evidence shows that polymorphisms in the SOD2 gene affect the elimination of the reactive oxygen species (ROS) generated in mitochondria. The aim of this study was to determine whether the functional rs4880 SNP in the SOD2 gene is a risk factor associated with aMCI and sporadic AD. 216 subjects with aMCI, 355 with AD, and 245 controls have been studied. The SNP rs4880 of the SOD2 gene was genotyped by RT-PCR and the APOE genotype was determined by PCR and RFLPs. Different multinomial logistic regression models were used to determine the risk levels for aMCI and AD. Although the T allele of the SOD2 rs4880 SNP gene (rs4880-T) is not an independent risk for aMCI or AD, this allele increases the risk to aMCI patients carrying at least one APOEε4 allele. Moreover, rs4880-T allele and APOEε4 allele combination has been found to produce an increased risk for AD compared to aMCI reference patients. These results suggest that APOEε4 and rs4880-T genotype may be a risk for aMCI and a predictor of progression from aMCI to AD. Hindawi Publishing Corporation 2015 2015-12-01 /pmc/articles/PMC4678069/ /pubmed/26696693 http://dx.doi.org/10.1155/2015/746329 Text en Copyright © 2015 David Gamarra et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gamarra, David
Elcoroaristizabal, Xabier
Fernández-Martínez, Manuel
de Pancorbo, Marian M.
Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele
title Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele
title_full Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele
title_fullStr Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele
title_full_unstemmed Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele
title_short Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele
title_sort association of the c47t polymorphism in sod2 with amnestic mild cognitive impairment and alzheimer's disease in carriers of the apoeε4 allele
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678069/
https://www.ncbi.nlm.nih.gov/pubmed/26696693
http://dx.doi.org/10.1155/2015/746329
work_keys_str_mv AT gamarradavid associationofthec47tpolymorphisminsod2withamnesticmildcognitiveimpairmentandalzheimersdiseaseincarriersoftheapoee4allele
AT elcoroaristizabalxabier associationofthec47tpolymorphisminsod2withamnesticmildcognitiveimpairmentandalzheimersdiseaseincarriersoftheapoee4allele
AT fernandezmartinezmanuel associationofthec47tpolymorphisminsod2withamnesticmildcognitiveimpairmentandalzheimersdiseaseincarriersoftheapoee4allele
AT depancorbomarianm associationofthec47tpolymorphisminsod2withamnesticmildcognitiveimpairmentandalzheimersdiseaseincarriersoftheapoee4allele