Cargando…

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

Poly(ADP-ribose)polymerase 1 (PARP-1) is a key eukaryotic stress sensor that responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic damage. A burst of poly(ADP-ribose) synthesis initiates DNA damage response, whereas PARP-1 inhibition kills BRCA-deficient tumor cells selec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eustermann, Sebastian, Wu, Wing-Fung, Langelier, Marie-France, Yang, Ji-Chun, Easton, Laura E., Riccio, Amanda A., Pascal, John M., Neuhaus, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678113/ https://www.ncbi.nlm.nih.gov/pubmed/26626479 http://dx.doi.org/10.1016/j.molcel.2015.10.032

Ejemplares similares

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
por: Langelier, Marie-France, et al.
Publicado: (2014)

Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level
por: Sefer, Anna, et al.
Publicado: (2022)

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger
por: Eustermann, Sebastian, et al.
Publicado: (2011)

Corrigendum to “The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger” [J. Mol. Biol. 407 (2011) 149–170]
por: Eustermann, Sebastian, et al.
Publicado: (2012)

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA
por: Langelier, Marie-France, et al.
Publicado: (2023)

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
por: Ogden, Tom E H, et al.
Publicado: (2021)

DNA-dependent SUMO modification of PARP-1()
por: Zilio, Nicola, et al.
Publicado: (2013)

ARF induction in response to DNA strand breaks is regulated by PARP1
por: Orlando, Giulia, et al.
Publicado: (2014)

PARP retains Ku at double-strand breaks
por: Short, Ben
Publicado: (2011)

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
por: Shao, Zhengping, et al.
Publicado: (2020)

Deciphering the functional mechanism of zinc ions of PARP1 binding with single strand breaks and double strand breaks
por: Sun, Shuya, et al.
Publicado: (2022)

The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair
por: Fenton, Amanda L., et al.
Publicado: (2013)

Structural basis for DNA break recognition by ARTD2/PARP2
por: Obaji, Ezeogo, et al.
Publicado: (2018)

Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks
por: Bell, Nicholas A. W., et al.
Publicado: (2023)

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery
por: Noël, Georges, et al.
Publicado: (2003)

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
por: Caron, Marie-Christine, et al.
Publicado: (2019)

The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions
por: Bilkis, Rabeya, et al.
Publicado: (2023)

PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks
por: Krietsch, Jana, et al.
Publicado: (2012)

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
por: Wang, Minli, et al.
Publicado: (2006)

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks
por: Cheng, Qiao, et al.
Publicado: (2011)

NAD(+) analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains
por: Langelier, Marie-France, et al.
Publicado: (2018)

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility
por: Godon, Camille, et al.
Publicado: (2008)

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks
por: Van Meter, Michael, et al.
Publicado: (2016)

Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ
por: Kalasova, Ilona, et al.
Publicado: (2019)

Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation
por: Yang, Seungyeon, et al.
Publicado: (2023)

Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging
por: Sukhanova, Maria V., et al.
Publicado: (2016)

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
por: Couto, C. Anne-Marie, et al.
Publicado: (2011)

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
por: Riccio, Amanda A., et al.
Publicado: (2016)

Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase
por: Brissett, Nigel C., et al.
Publicado: (2013)

Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors
por: Yang, Guang, et al.
Publicado: (2018)

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1
por: Gaullier, Guillaume, et al.
Publicado: (2020)

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
por: Langelier, Marie-France, et al.
Publicado: (2021)

Repair at Single Targeted DNA Double-Strand Breaks in Pluripotent and Differentiated Human Cells
por: Fung, Hua, et al.
Publicado: (2011)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
por: Mansour, Wael Y., et al.
Publicado: (2010)

Genome-Wide Mapping of DNA Strand Breaks
por: Leduc, Frédéric, et al.
Publicado: (2011)

Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair
por: Johnson, Rebecca, et al.
Publicado: (2007)

Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy
por: Sultanov, Daniel, et al.
Publicado: (2017)

Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair
por: Campalans, Anna, et al.
Publicado: (2013)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pi648rstaouib7cjd96k8rj81j