Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study

PURPOSE: The best screening practice for Lynch syndrome (LS) in endometrial cancer (EC) remains unknown. We sought to determine whether tumor microsatellite instability (MSI) typing along with immunohistochemistry (IHC) and MLH1 methylation analysis can help identify women with LS. PATIENTS AND METH...

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Detalles Bibliográficos
Autores principales: Goodfellow, Paul J., Billingsley, Caroline C., Lankes, Heather A., Ali, Shamshad, Cohn, David E., Broaddus, Russell J., Ramirez, Nilsa, Pritchard, Colin C., Hampel, Heather, Chassen, Alexis S., Simmons, Luke V., Schmidt, Amy P., Gao, Feng, Brinton, Louise A., Backes, Floor, Landrum, Lisa M., Geller, Melissa A., DiSilvestro, Paul A., Pearl, Michael L., Lele, Shashikant B., Powell, Matthew A., Zaino, Richard J., Mutch, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2015
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678181/
https://www.ncbi.nlm.nih.gov/pubmed/26552419
http://dx.doi.org/10.1200/JCO.2015.63.9518

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