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In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity

The great phylogenetic diversity of microalgae is corresponded by a wide arrange of interesting and useful metabolites. Nonetheless metabolic engineering in microalgae has been limited, since specific transformation tools must be developed for each species for either the nuclear or chloroplast genom...

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Autores principales: Gimpel, Javier A., Henríquez, Vitalia, Mayfield, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678203/
https://www.ncbi.nlm.nih.gov/pubmed/26696985
http://dx.doi.org/10.3389/fmicb.2015.01376
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author Gimpel, Javier A.
Henríquez, Vitalia
Mayfield, Stephen P.
author_facet Gimpel, Javier A.
Henríquez, Vitalia
Mayfield, Stephen P.
author_sort Gimpel, Javier A.
collection PubMed
description The great phylogenetic diversity of microalgae is corresponded by a wide arrange of interesting and useful metabolites. Nonetheless metabolic engineering in microalgae has been limited, since specific transformation tools must be developed for each species for either the nuclear or chloroplast genomes. Microalgae as production platforms for metabolites offer several advantages over plants and other microorganisms, like the ability of GMO containment and reduced costs in culture media, respectively. Currently, microalgae have proved particularly well suited for the commercial production of omega-3 fatty acids and carotenoids. Therefore most metabolic engineering strategies have been developed for these metabolites. Microalgal biofuels have also drawn great attention recently, resulting in efforts for improving the production of hydrogen and photosynthates, particularly triacylglycerides. Metabolic pathways of microalgae have also been manipulated in order to improve photosynthetic growth under specific conditions and for achieving trophic conversion. Although these pathways are not strictly related to secondary metabolites, the synthetic biology approaches could potentially be translated to this field and will also be discussed.
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spelling pubmed-46782032015-12-22 In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity Gimpel, Javier A. Henríquez, Vitalia Mayfield, Stephen P. Front Microbiol Microbiology The great phylogenetic diversity of microalgae is corresponded by a wide arrange of interesting and useful metabolites. Nonetheless metabolic engineering in microalgae has been limited, since specific transformation tools must be developed for each species for either the nuclear or chloroplast genomes. Microalgae as production platforms for metabolites offer several advantages over plants and other microorganisms, like the ability of GMO containment and reduced costs in culture media, respectively. Currently, microalgae have proved particularly well suited for the commercial production of omega-3 fatty acids and carotenoids. Therefore most metabolic engineering strategies have been developed for these metabolites. Microalgal biofuels have also drawn great attention recently, resulting in efforts for improving the production of hydrogen and photosynthates, particularly triacylglycerides. Metabolic pathways of microalgae have also been manipulated in order to improve photosynthetic growth under specific conditions and for achieving trophic conversion. Although these pathways are not strictly related to secondary metabolites, the synthetic biology approaches could potentially be translated to this field and will also be discussed. Frontiers Media S.A. 2015-12-15 /pmc/articles/PMC4678203/ /pubmed/26696985 http://dx.doi.org/10.3389/fmicb.2015.01376 Text en Copyright © 2015 Gimpel, Henríquez and Mayfield. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Gimpel, Javier A.
Henríquez, Vitalia
Mayfield, Stephen P.
In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity
title In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity
title_full In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity
title_fullStr In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity
title_full_unstemmed In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity
title_short In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity
title_sort in metabolic engineering of eukaryotic microalgae: potential and challenges come with great diversity
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678203/
https://www.ncbi.nlm.nih.gov/pubmed/26696985
http://dx.doi.org/10.3389/fmicb.2015.01376
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