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Mean platelet volume in young children with urinary tract infection

Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute py...

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Detalles Bibliográficos
Autores principales: Lee, I Re, Shin, Jae Il, Park, Se Jin, Oh, Ji Young, Kim, Ji Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678298/
https://www.ncbi.nlm.nih.gov/pubmed/26666588
http://dx.doi.org/10.1038/srep18072
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author Lee, I Re
Shin, Jae Il
Park, Se Jin
Oh, Ji Young
Kim, Ji Hong
author_facet Lee, I Re
Shin, Jae Il
Park, Se Jin
Oh, Ji Young
Kim, Ji Hong
author_sort Lee, I Re
collection PubMed
description Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. MPV, platelet distribution width (PDW) platelet count, and other infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]) were measured. WBC (P = 0.001), ESR (P = 0.005), CRP (P < 0.001) and MPV levels (P = 0.011) were significantly higher in the APN group than those in the lower UTI group. MPV positively correlated with PDW, CRP and negatively with platelet count. Multiple logistic regression analyses showed that CRP and MPV were independent predictive factors for APN patients. However, the area under the Receiver Operating Characteristic (ROC) curve analysis for MPV was lower than CRP. Our results suggest that MPV can be an inflammatory marker in UTI, but the predictive value of MPV was not superior to CRP in the diagnosis of APN.
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spelling pubmed-46782982015-12-17 Mean platelet volume in young children with urinary tract infection Lee, I Re Shin, Jae Il Park, Se Jin Oh, Ji Young Kim, Ji Hong Sci Rep Article Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. MPV, platelet distribution width (PDW) platelet count, and other infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]) were measured. WBC (P = 0.001), ESR (P = 0.005), CRP (P < 0.001) and MPV levels (P = 0.011) were significantly higher in the APN group than those in the lower UTI group. MPV positively correlated with PDW, CRP and negatively with platelet count. Multiple logistic regression analyses showed that CRP and MPV were independent predictive factors for APN patients. However, the area under the Receiver Operating Characteristic (ROC) curve analysis for MPV was lower than CRP. Our results suggest that MPV can be an inflammatory marker in UTI, but the predictive value of MPV was not superior to CRP in the diagnosis of APN. Nature Publishing Group 2015-12-15 /pmc/articles/PMC4678298/ /pubmed/26666588 http://dx.doi.org/10.1038/srep18072 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lee, I Re
Shin, Jae Il
Park, Se Jin
Oh, Ji Young
Kim, Ji Hong
Mean platelet volume in young children with urinary tract infection
title Mean platelet volume in young children with urinary tract infection
title_full Mean platelet volume in young children with urinary tract infection
title_fullStr Mean platelet volume in young children with urinary tract infection
title_full_unstemmed Mean platelet volume in young children with urinary tract infection
title_short Mean platelet volume in young children with urinary tract infection
title_sort mean platelet volume in young children with urinary tract infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678298/
https://www.ncbi.nlm.nih.gov/pubmed/26666588
http://dx.doi.org/10.1038/srep18072
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