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Mean platelet volume in young children with urinary tract infection
Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute py...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678298/ https://www.ncbi.nlm.nih.gov/pubmed/26666588 http://dx.doi.org/10.1038/srep18072 |
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author | Lee, I Re Shin, Jae Il Park, Se Jin Oh, Ji Young Kim, Ji Hong |
author_facet | Lee, I Re Shin, Jae Il Park, Se Jin Oh, Ji Young Kim, Ji Hong |
author_sort | Lee, I Re |
collection | PubMed |
description | Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. MPV, platelet distribution width (PDW) platelet count, and other infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]) were measured. WBC (P = 0.001), ESR (P = 0.005), CRP (P < 0.001) and MPV levels (P = 0.011) were significantly higher in the APN group than those in the lower UTI group. MPV positively correlated with PDW, CRP and negatively with platelet count. Multiple logistic regression analyses showed that CRP and MPV were independent predictive factors for APN patients. However, the area under the Receiver Operating Characteristic (ROC) curve analysis for MPV was lower than CRP. Our results suggest that MPV can be an inflammatory marker in UTI, but the predictive value of MPV was not superior to CRP in the diagnosis of APN. |
format | Online Article Text |
id | pubmed-4678298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46782982015-12-17 Mean platelet volume in young children with urinary tract infection Lee, I Re Shin, Jae Il Park, Se Jin Oh, Ji Young Kim, Ji Hong Sci Rep Article Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. MPV, platelet distribution width (PDW) platelet count, and other infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]) were measured. WBC (P = 0.001), ESR (P = 0.005), CRP (P < 0.001) and MPV levels (P = 0.011) were significantly higher in the APN group than those in the lower UTI group. MPV positively correlated with PDW, CRP and negatively with platelet count. Multiple logistic regression analyses showed that CRP and MPV were independent predictive factors for APN patients. However, the area under the Receiver Operating Characteristic (ROC) curve analysis for MPV was lower than CRP. Our results suggest that MPV can be an inflammatory marker in UTI, but the predictive value of MPV was not superior to CRP in the diagnosis of APN. Nature Publishing Group 2015-12-15 /pmc/articles/PMC4678298/ /pubmed/26666588 http://dx.doi.org/10.1038/srep18072 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lee, I Re Shin, Jae Il Park, Se Jin Oh, Ji Young Kim, Ji Hong Mean platelet volume in young children with urinary tract infection |
title | Mean platelet volume in young children with urinary tract infection |
title_full | Mean platelet volume in young children with urinary tract infection |
title_fullStr | Mean platelet volume in young children with urinary tract infection |
title_full_unstemmed | Mean platelet volume in young children with urinary tract infection |
title_short | Mean platelet volume in young children with urinary tract infection |
title_sort | mean platelet volume in young children with urinary tract infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678298/ https://www.ncbi.nlm.nih.gov/pubmed/26666588 http://dx.doi.org/10.1038/srep18072 |
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