Cargando…

Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells

BACKGROUND: Accumulating evidence has indicated the relationship between the systemic immune system and the central nervous system including the inner ear. RESULTS: We have shown that age-related developments of T-cell dysfunction, hearing loss, and degeneration of cochlear spiral ganglion (SG) neur...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwai, Hiroshi, Inaba, Muneo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678479/
https://www.ncbi.nlm.nih.gov/pubmed/26673738
http://dx.doi.org/10.1186/s12979-015-0053-9
_version_ 1782405447548928000
author Iwai, Hiroshi
Inaba, Muneo
author_facet Iwai, Hiroshi
Inaba, Muneo
author_sort Iwai, Hiroshi
collection PubMed
description BACKGROUND: Accumulating evidence has indicated the relationship between the systemic immune system and the central nervous system including the inner ear. RESULTS: We have shown that age-related developments of T-cell dysfunction, hearing loss, and degeneration of cochlear spiral ganglion (SG) neurons observed in 6-month-old mice were recovered in 12 months old mice which previously given fetal thymus transplants twice. We have also demonstrated that CD4(+) T cells expressing interleukin 1 receptor type 2 (IL-1R2) and naturally occurring regulatory T cells (nTregs), which expanded in aged 12-month-old mice, were reduced in the thymus-grafted mice of the same age. CONCLUSION: It is conceivable that the rejuvenation of systemic immune function by fetal thymus grafts contributes not only to the activation of cellular immunity but also to the decrease of IL-1R2(+) CD4(+) T cells or nTregs, which cells accelerate both age-related hearing loss (AHL) and neurodegeneration of the cochlear neurons. Further studies on the interactions among IL-1R2 expression on CD4(+) T cells, Tregs, and neuronal cells and also on the relationships between fetal thymus grafting and the rejuvenation of systemic immunity should be designed in order to advance towards therapeutic effects on neurosenescence, including AHL.
format Online
Article
Text
id pubmed-4678479
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-46784792015-12-16 Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells Iwai, Hiroshi Inaba, Muneo Immun Ageing Research BACKGROUND: Accumulating evidence has indicated the relationship between the systemic immune system and the central nervous system including the inner ear. RESULTS: We have shown that age-related developments of T-cell dysfunction, hearing loss, and degeneration of cochlear spiral ganglion (SG) neurons observed in 6-month-old mice were recovered in 12 months old mice which previously given fetal thymus transplants twice. We have also demonstrated that CD4(+) T cells expressing interleukin 1 receptor type 2 (IL-1R2) and naturally occurring regulatory T cells (nTregs), which expanded in aged 12-month-old mice, were reduced in the thymus-grafted mice of the same age. CONCLUSION: It is conceivable that the rejuvenation of systemic immune function by fetal thymus grafts contributes not only to the activation of cellular immunity but also to the decrease of IL-1R2(+) CD4(+) T cells or nTregs, which cells accelerate both age-related hearing loss (AHL) and neurodegeneration of the cochlear neurons. Further studies on the interactions among IL-1R2 expression on CD4(+) T cells, Tregs, and neuronal cells and also on the relationships between fetal thymus grafting and the rejuvenation of systemic immunity should be designed in order to advance towards therapeutic effects on neurosenescence, including AHL. BioMed Central 2015-12-15 /pmc/articles/PMC4678479/ /pubmed/26673738 http://dx.doi.org/10.1186/s12979-015-0053-9 Text en © Iwai and Inaba. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Iwai, Hiroshi
Inaba, Muneo
Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells
title Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells
title_full Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells
title_fullStr Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells
title_full_unstemmed Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells
title_short Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells
title_sort fetal thymus graft enables recovery from age-related hearing loss and expansion of cd4-positive t cells expressing il-1 receptor type 2 and regulatory t cells
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678479/
https://www.ncbi.nlm.nih.gov/pubmed/26673738
http://dx.doi.org/10.1186/s12979-015-0053-9
work_keys_str_mv AT iwaihiroshi fetalthymusgraftenablesrecoveryfromagerelatedhearinglossandexpansionofcd4positivetcellsexpressingil1receptortype2andregulatorytcells
AT inabamuneo fetalthymusgraftenablesrecoveryfromagerelatedhearinglossandexpansionofcd4positivetcellsexpressingil1receptortype2andregulatorytcells