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Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation

BACKGROUND: Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) hydrolyzes dUTP to dUMP and pyrophosphate to maintain the cellular thymine-uracil ratio. dUTPase is also a target for cancer chemotherapy. However, the mechanism defining its substrate affinity remains unclear. Sequence comparisons...

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Detalles Bibliográficos
Autores principales:	Inoguchi, Noriko, Chaiseeda, Kittichai, Yamanishi, Mamoru, Kim, Moon Ki, Jang, Yunho, Bajaj, Mamta, Chia, Catherine P., Becker, Donald F., Moriyama, Hideaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678481/ https://www.ncbi.nlm.nih.gov/pubmed/26666293 http://dx.doi.org/10.1186/s13104-015-1760-1

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