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Enantioselective Desymmetrization of Prochiral Cyclohexanones by Organocatalytic Intramolecular Michael Additions to α,β-Unsaturated Esters**
A new catalytic asymmetric desymmetrization reaction for the synthesis of enantioenriched derivatives of 2-azabicyclo[3.3.1]nonane, a key motif common to many alkaloids, has been developed. Employing a cyclohexanediamine-derived primary amine organocatalyst, a range of prochiral cyclohexanone deriva...
Autores principales: | Gammack Yamagata, Adam D, Datta, Swarup, Jackson, Kelvin E, Stegbauer, Linus, Paton, Robert S, Dixon, Darren J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678487/ https://www.ncbi.nlm.nih.gov/pubmed/25727215 http://dx.doi.org/10.1002/anie.201411924 |
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