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Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis

OBJECTIVE: To critically evaluate the effect of red clover on hot flash, endometrial thickness, and hormones status in postmenopausal and peri- and post-menopausal women. MATERIALS AND METHODS: MEDLINE (1966 to July 2014), Scopus (1990 to July 2014), and the Cochrane Central Register of Controlled T...

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Autores principales: Ghazanfarpour, Masumeh, Sadeghi, Ramin, Latifnejad Roudsari, Robab, Mirzaii Najmabadi, Khadijeh, mousavi bazaz, Mojtaba, abdolahian, Somayeh, Khadivzadeh, Talat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2015
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678495/
https://www.ncbi.nlm.nih.gov/pubmed/26693407
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author Ghazanfarpour, Masumeh
Sadeghi, Ramin
Latifnejad Roudsari, Robab
Mirzaii Najmabadi, Khadijeh
mousavi bazaz, Mojtaba
abdolahian, Somayeh
Khadivzadeh, Talat
author_facet Ghazanfarpour, Masumeh
Sadeghi, Ramin
Latifnejad Roudsari, Robab
Mirzaii Najmabadi, Khadijeh
mousavi bazaz, Mojtaba
abdolahian, Somayeh
Khadivzadeh, Talat
author_sort Ghazanfarpour, Masumeh
collection PubMed
description OBJECTIVE: To critically evaluate the effect of red clover on hot flash, endometrial thickness, and hormones status in postmenopausal and peri- and post-menopausal women. MATERIALS AND METHODS: MEDLINE (1966 to July 2014), Scopus (1990 to July 2014), and the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2014) were searched for published randomized controlled Trials (RCTs). RESULTS: Of 183 relevant publication trials, 11 RCTs met the inclusion criteria. The mean hot flashes frequency in red clover was lower than the control groups (MD -1.99; p=0.067). There was larger decrease in FSH (SMD -0.812; CI: -1.93 to 0.312; p=0.157) and SHBG (SMD -0.128; CI-0.425 to 0.170; P=0.4) in red clover group, compared with placebo, which was not however statistically significant. LH (SMD 0.144; CI-0.097 to 0.384, p=0.242), estradiol (SMD 0.240; CI-0.001 to 0.482, p=0.051), testosterone (MD 0.083; CI: -0.560 to 0.726; p=0.901), and endometrial thickness (SDM 0.022; CI: -0.380 to 0.424, p=0.915) showed greater increase in red clover, compared with placebo, although the effect of estradiol was only significant. CONCLUSION: Red clover had a positive effect of alleviating hot flash in menopausal women. Our data, however, suggested very slight changes in FSH, LH, testosterone, and SHBG and significant effect in estrogen status by red clover consumption. However, the interpretation of results of the current study is limited due to methodological flaws of the included studies, menopause status, and large heterogeneity among them. Further trials are still needed to confirm the current finding.
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spelling pubmed-46784952015-12-21 Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis Ghazanfarpour, Masumeh Sadeghi, Ramin Latifnejad Roudsari, Robab Mirzaii Najmabadi, Khadijeh mousavi bazaz, Mojtaba abdolahian, Somayeh Khadivzadeh, Talat Avicenna J Phytomed Review Article OBJECTIVE: To critically evaluate the effect of red clover on hot flash, endometrial thickness, and hormones status in postmenopausal and peri- and post-menopausal women. MATERIALS AND METHODS: MEDLINE (1966 to July 2014), Scopus (1990 to July 2014), and the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2014) were searched for published randomized controlled Trials (RCTs). RESULTS: Of 183 relevant publication trials, 11 RCTs met the inclusion criteria. The mean hot flashes frequency in red clover was lower than the control groups (MD -1.99; p=0.067). There was larger decrease in FSH (SMD -0.812; CI: -1.93 to 0.312; p=0.157) and SHBG (SMD -0.128; CI-0.425 to 0.170; P=0.4) in red clover group, compared with placebo, which was not however statistically significant. LH (SMD 0.144; CI-0.097 to 0.384, p=0.242), estradiol (SMD 0.240; CI-0.001 to 0.482, p=0.051), testosterone (MD 0.083; CI: -0.560 to 0.726; p=0.901), and endometrial thickness (SDM 0.022; CI: -0.380 to 0.424, p=0.915) showed greater increase in red clover, compared with placebo, although the effect of estradiol was only significant. CONCLUSION: Red clover had a positive effect of alleviating hot flash in menopausal women. Our data, however, suggested very slight changes in FSH, LH, testosterone, and SHBG and significant effect in estrogen status by red clover consumption. However, the interpretation of results of the current study is limited due to methodological flaws of the included studies, menopause status, and large heterogeneity among them. Further trials are still needed to confirm the current finding. Mashhad University of Medical Sciences 2015 /pmc/articles/PMC4678495/ /pubmed/26693407 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ghazanfarpour, Masumeh
Sadeghi, Ramin
Latifnejad Roudsari, Robab
Mirzaii Najmabadi, Khadijeh
mousavi bazaz, Mojtaba
abdolahian, Somayeh
Khadivzadeh, Talat
Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
title Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
title_full Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
title_fullStr Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
title_full_unstemmed Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
title_short Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
title_sort effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678495/
https://www.ncbi.nlm.nih.gov/pubmed/26693407
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