Targeting the indoleamine 2,3-dioxygenase pathway in cancer

Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of...

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Detalles Bibliográficos
Autores principales: Moon, Yong Wha, Hajjar, Joud, Hwu, Patrick, Naing, Aung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678703/
https://www.ncbi.nlm.nih.gov/pubmed/26674411
http://dx.doi.org/10.1186/s40425-015-0094-9
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author Moon, Yong Wha
Hajjar, Joud
Hwu, Patrick
Naing, Aung
author_facet Moon, Yong Wha
Hajjar, Joud
Hwu, Patrick
Naing, Aung
author_sort Moon, Yong Wha
collection PubMed
description Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development.
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spelling pubmed-46787032015-12-16 Targeting the indoleamine 2,3-dioxygenase pathway in cancer Moon, Yong Wha Hajjar, Joud Hwu, Patrick Naing, Aung J Immunother Cancer Review Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development. BioMed Central 2015-12-15 /pmc/articles/PMC4678703/ /pubmed/26674411 http://dx.doi.org/10.1186/s40425-015-0094-9 Text en © Moon et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Moon, Yong Wha
Hajjar, Joud
Hwu, Patrick
Naing, Aung
Targeting the indoleamine 2,3-dioxygenase pathway in cancer
title Targeting the indoleamine 2,3-dioxygenase pathway in cancer
title_full Targeting the indoleamine 2,3-dioxygenase pathway in cancer
title_fullStr Targeting the indoleamine 2,3-dioxygenase pathway in cancer
title_full_unstemmed Targeting the indoleamine 2,3-dioxygenase pathway in cancer
title_short Targeting the indoleamine 2,3-dioxygenase pathway in cancer
title_sort targeting the indoleamine 2,3-dioxygenase pathway in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678703/
https://www.ncbi.nlm.nih.gov/pubmed/26674411
http://dx.doi.org/10.1186/s40425-015-0094-9
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