Cargando…

Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL

BACKGROUND: The clinical application of TRAIL receptor agonists as a novel cancer therapy has been tempered by heterogeneity in tumour responses. This is illustrated in breast cancer, where TRAIL is cytotoxic in cell lines of mesenchymal origin but refractory in lines with an epithelial-like phenoty...

Descripción completa

Detalles Bibliográficos
Autores principales:	French, Rhiannon, Hayward, Olivia, Jones, Samuel, Yang, William, Clarkson, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678708/ https://www.ncbi.nlm.nih.gov/pubmed/26667821 http://dx.doi.org/10.1186/s12943-015-0478-y

Ejemplares similares

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP
por: Tsuchiya, Yuichi, et al.
Publicado: (2015)

Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP
por: Shi, Yuan, et al.
Publicado: (2013)

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1
por: Lemke, J, et al.
Publicado: (2014)

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation
por: Henrich, C J, et al.
Publicado: (2015)

Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP
por: Holmgren, Christian, et al.
Publicado: (2022)

Inhibition of Methyltransferases Accelerates Degradation of cFLIP and Sensitizes B-Cell Lymphoma Cells to TRAIL-Induced Apoptosis
por: Braun, Frank K., et al.
Publicado: (2015)

YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation
por: Chandrasekaran, Arun Pandian, et al.
Publicado: (2020)

cFLIP expression is altered in severe corticosteroid-resistant asthma
por: Lazarev, Dennis, et al.
Publicado: (2014)

cFLIP overexpression in T cells in thymoma-associated myasthenia gravis
por: Belharazem, Djeda, et al.
Publicado: (2015)

Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells
por: Seo, Ok-Won, et al.
Publicado: (2012)

Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling
por: Du, Juan, et al.
Publicado: (2016)

Identification and Characterization of the Interaction Site between cFLIP(L) and Calmodulin
por: Gaidos, Gabriel, et al.
Publicado: (2015)

Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells
por: Kleinesudeik, Lara, et al.
Publicado: (2018)

cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition
por: Padmanabhan, Chandrasekhar, et al.
Publicado: (2017)

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
por: Jeon, Mi-Yeon, et al.
Publicado: (2018)

Accelerated degradation of cFLIP(L) and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis
por: Lee, So-Ra, et al.
Publicado: (2019)

Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
por: Piggott, Luke, et al.
Publicado: (2015)

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells
por: Huangfu, Jingru, et al.
Publicado: (2021)

Emodin Suppresses Hyperglycemia-Induced Proliferation and Fibronectin Expression in Mesangial Cells via Inhibiting cFLIP
por: Gao, Junjie, et al.
Publicado: (2014)

FADD regulates NF-κB activation and promotes ubiquitination of cFLIP(L) to induce apoptosis
por: Ranjan, Kishu, et al.
Publicado: (2016)

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP
por: Feoktistova, Maria, et al.
Publicado: (2020)

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells
por: Mora-Molina, Rocío, et al.
Publicado: (2022)

ShDcR3 sensitizes TRAIL-resistant HCC cells by inducing caspase-dependent apoptosis while suppressing NF-κB dependent cFLIP(L) expression
por: Liang, Dong-Yu, et al.
Publicado: (2018)

Independent Induction of Caspase-8 and cFLIP Expression during Colorectal Carcinogenesis in Sporadic and HNPCC Adenomas and Carcinomas
por: Heijink, D. M., et al.
Publicado: (2007)

Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling
por: Belharazem, Djeda, et al.
Publicado: (2017)

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair
por: Martinez Lagunas, Kristel, et al.
Publicado: (2023)

Expressions of IGFBP-5, cFLIP in cervical intraepithelial neoplasia, cervical carcinoma and their clinical significances: a molecular pathology
por: Hou, Xue-Jing, et al.
Publicado: (2009)

Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway
por: Liu, Xiu-Fen, et al.
Publicado: (2017)

Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP
por: Hirpara, Jayshree L., et al.
Publicado: (2019)

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis
por: Suk, Fat-Moon, et al.
Publicado: (2021)

Sensitization of glycoengineered interferon-β1a-resistant cancer cells by cFLIP inhibition for enhanced anti-cancer therapy
por: Kim, Tae-Eun, et al.
Publicado: (2017)

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L)
por: Nakabayashi, Osamu, et al.
Publicado: (2021)

The deubiquitinase Usp27x as a novel regulator of cFLIP(L) protein expression and sensitizer to death-receptor-induced apoptosis
por: Dold, Manuel Nico, et al.
Publicado: (2022)

Expression and localization of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic factor, in corpora lutea during the estrous cycle and pregnancy in Thai swamp buffalo (Bubalus bubalis)
por: WONGPANIT, Kannika, et al.
Publicado: (2019)

Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells
por: Kohl, T, et al.
Publicado: (2013)

Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP)
por: Baratchian, Mehdi, et al.
Publicado: (2016)

LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2–cFLIP–NF-κB signaling axis
por: Wu, Guojin, et al.
Publicado: (2021)

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
por: Feoktistova, Maria, et al.
Publicado: (2011)

Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
por: Piggott, Luke, et al.
Publicado: (2011)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rh2dvvodlft5btuv0a5l7knkdv