Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism

Many dsDNA viruses encode DNA-packaging terminases, each containing a nuclease domain that resolves concatemeric DNA into genome-length units. Terminase nucleases resemble the RNase H-superfamily nucleotidyltransferases in folds, and share a two-metal-ion catalytic mechanism. Here we show that resid...

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Detalles Bibliográficos
Autores principales: Zhao, Haiyan, Lin, Zihan, Lynn, Anna Y., Varnado, Brittany, Beutler, John A., Murelli, Ryan P., Le Grice, Stuart F. J., Tang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678813/
https://www.ncbi.nlm.nih.gov/pubmed/26450964
http://dx.doi.org/10.1093/nar/gkv1018

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