Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery

CRISPR immunity depends on acquisition of fragments of foreign DNA into CRISPR arrays. For type I-E CRISPR–Cas systems two modes of spacer acquisition, naïve and primed adaptation, were described. Naïve adaptation requires just two most conserved Cas1 and Cas2 proteins; it leads to spacer acquisitio...

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Detalles Bibliográficos
Autores principales: Vorontsova, Daria, Datsenko, Kirill A., Medvedeva, Sofia, Bondy-Denomy, Joseph, Savitskaya, Ekaterina E., Pougach, Ksenia, Logacheva, Maria, Wiedenheft, Blake, Davidson, Alan R., Severinov, Konstantin, Semenova, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678832/
https://www.ncbi.nlm.nih.gov/pubmed/26586803
http://dx.doi.org/10.1093/nar/gkv1261

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