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Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. We report here that the activities of two Dnmt2 homologs, Pmt1 from Schizosaccharomyces pombe and DnmA from Dictyostelium discoideum, are strongly stimulated by prior queuosine (Q) modification of the substrate tRNA...

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Detalles Bibliográficos
Autores principales:	Müller, Martin, Hartmann, Mark, Schuster, Isabelle, Bender, Sebastian, Thüring, Kathrin L., Helm, Mark, Katze, Jon R., Nellen, Wolfgang, Lyko, Frank, Ehrenhofer-Murray, Ann E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678861/ https://www.ncbi.nlm.nih.gov/pubmed/26424849 http://dx.doi.org/10.1093/nar/gkv980

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