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Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data

Cohen’s lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set...

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Detalles Bibliográficos
Autores principales: Cuttler, Jerry M., Sanders, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679206/
https://www.ncbi.nlm.nih.gov/pubmed/26740812
http://dx.doi.org/10.1177/1559325815615102
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author Cuttler, Jerry M.
Sanders, Charles L.
author_facet Cuttler, Jerry M.
Sanders, Charles L.
author_sort Cuttler, Jerry M.
collection PubMed
description Cohen’s lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set the radon limit near the NOAEL to avoid the risk of losing a health benefit. Assuming that dogs model humans, data from a study on inhaled plutonium dioxide particulates in dogs were assessed, and the NOAEL for radon-induced lung tumors was estimated to be about 2100 Bq/m(3). The US Environmental Protection Agency should consider raising its radon action level from 150 to at least 1000 Bq/m(3).
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spelling pubmed-46792062016-01-06 Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data Cuttler, Jerry M. Sanders, Charles L. Dose Response Article Cohen’s lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set the radon limit near the NOAEL to avoid the risk of losing a health benefit. Assuming that dogs model humans, data from a study on inhaled plutonium dioxide particulates in dogs were assessed, and the NOAEL for radon-induced lung tumors was estimated to be about 2100 Bq/m(3). The US Environmental Protection Agency should consider raising its radon action level from 150 to at least 1000 Bq/m(3). SAGE Publications 2015-11-02 /pmc/articles/PMC4679206/ /pubmed/26740812 http://dx.doi.org/10.1177/1559325815615102 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Cuttler, Jerry M.
Sanders, Charles L.
Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data
title Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data
title_full Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data
title_fullStr Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data
title_full_unstemmed Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data
title_short Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data
title_sort threshold for radon-induced lung cancer from inhaled plutonium data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679206/
https://www.ncbi.nlm.nih.gov/pubmed/26740812
http://dx.doi.org/10.1177/1559325815615102
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