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Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data
Cohen’s lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679206/ https://www.ncbi.nlm.nih.gov/pubmed/26740812 http://dx.doi.org/10.1177/1559325815615102 |
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author | Cuttler, Jerry M. Sanders, Charles L. |
author_facet | Cuttler, Jerry M. Sanders, Charles L. |
author_sort | Cuttler, Jerry M. |
collection | PubMed |
description | Cohen’s lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set the radon limit near the NOAEL to avoid the risk of losing a health benefit. Assuming that dogs model humans, data from a study on inhaled plutonium dioxide particulates in dogs were assessed, and the NOAEL for radon-induced lung tumors was estimated to be about 2100 Bq/m(3). The US Environmental Protection Agency should consider raising its radon action level from 150 to at least 1000 Bq/m(3). |
format | Online Article Text |
id | pubmed-4679206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-46792062016-01-06 Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data Cuttler, Jerry M. Sanders, Charles L. Dose Response Article Cohen’s lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set the radon limit near the NOAEL to avoid the risk of losing a health benefit. Assuming that dogs model humans, data from a study on inhaled plutonium dioxide particulates in dogs were assessed, and the NOAEL for radon-induced lung tumors was estimated to be about 2100 Bq/m(3). The US Environmental Protection Agency should consider raising its radon action level from 150 to at least 1000 Bq/m(3). SAGE Publications 2015-11-02 /pmc/articles/PMC4679206/ /pubmed/26740812 http://dx.doi.org/10.1177/1559325815615102 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Article Cuttler, Jerry M. Sanders, Charles L. Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data |
title | Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data |
title_full | Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data |
title_fullStr | Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data |
title_full_unstemmed | Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data |
title_short | Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data |
title_sort | threshold for radon-induced lung cancer from inhaled plutonium data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679206/ https://www.ncbi.nlm.nih.gov/pubmed/26740812 http://dx.doi.org/10.1177/1559325815615102 |
work_keys_str_mv | AT cuttlerjerrym thresholdforradoninducedlungcancerfrominhaledplutoniumdata AT sanderscharlesl thresholdforradoninducedlungcancerfrominhaledplutoniumdata |