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Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdh(Q111) Model of HD

Huntington’s disease is a neurodegenerative disorder characterised primarily by motor abnormalities, and is caused by an expanded polyglutamine repeat in the huntingtin protein. Huntingtin dynamically shuttles between subcellular compartments, and the mutant huntingtin protein is mislocalised to cel...

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Detalles Bibliográficos
Autores principales:	Bowles, Kathryn R., Brooks, Simon P., Dunnett, Stephen B., Jones, Lesley
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679340/ https://www.ncbi.nlm.nih.gov/pubmed/26660732 http://dx.doi.org/10.1371/journal.pone.0144864

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