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Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA

To evaluate short-term outcomes of a new treatment for perforated diverticulitis with purulent peritonitis in a randomized controlled trial. BACKGROUND: Perforated diverticulitis with purulent peritonitis (Hinchey III) has traditionally been treated with surgery including colon resection and stoma (...

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Autores principales: Angenete, Eva, Thornell, Anders, Burcharth, Jakob, Pommergaard, Hans-Christian, Skullman, Stefan, Bisgaard, Thue, Jess, Per, Läckberg, Zoltan, Matthiessen, Peter, Heath, Jane, Rosenberg, Jacob, Haglind, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams, and Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679345/
https://www.ncbi.nlm.nih.gov/pubmed/25489672
http://dx.doi.org/10.1097/SLA.0000000000001061
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author Angenete, Eva
Thornell, Anders
Burcharth, Jakob
Pommergaard, Hans-Christian
Skullman, Stefan
Bisgaard, Thue
Jess, Per
Läckberg, Zoltan
Matthiessen, Peter
Heath, Jane
Rosenberg, Jacob
Haglind, Eva
author_facet Angenete, Eva
Thornell, Anders
Burcharth, Jakob
Pommergaard, Hans-Christian
Skullman, Stefan
Bisgaard, Thue
Jess, Per
Läckberg, Zoltan
Matthiessen, Peter
Heath, Jane
Rosenberg, Jacob
Haglind, Eva
author_sort Angenete, Eva
collection PubMed
description To evaluate short-term outcomes of a new treatment for perforated diverticulitis with purulent peritonitis in a randomized controlled trial. BACKGROUND: Perforated diverticulitis with purulent peritonitis (Hinchey III) has traditionally been treated with surgery including colon resection and stoma (Hartmann procedure) with considerable postoperative morbidity and mortality. Laparoscopic lavage has been suggested as a less invasive surgical treatment. METHODS: Laparoscopic lavage was compared with colon resection and stoma in a randomized controlled multicenter trial, DILALA (ISRCTN82208287). Initial diagnostic laparoscopy showing Hinchey III was followed by randomization. Clinical data was collected up to 12 weeks postoperatively. Results: Eighty-three patients were randomized, out of whom 39 patients in laparoscopic lavage and 36 patients in the Hartmann procedure groups were available for analysis. Morbidity and mortality after laparoscopic lavage did not differ when compared with the Hartmann procedure. Laparoscopic lavage resulted in shorter operating time, shorter time in the recovery unit, and shorter hospital stay. CONCLUSIONS: In this trial, laparoscopic lavage as treatment for patients with perforated diverticulitis Hinchey III was feasible and safe in the short-term.
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spelling pubmed-46793452015-12-21 Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA Angenete, Eva Thornell, Anders Burcharth, Jakob Pommergaard, Hans-Christian Skullman, Stefan Bisgaard, Thue Jess, Per Läckberg, Zoltan Matthiessen, Peter Heath, Jane Rosenberg, Jacob Haglind, Eva Ann Surg Original Articles To evaluate short-term outcomes of a new treatment for perforated diverticulitis with purulent peritonitis in a randomized controlled trial. BACKGROUND: Perforated diverticulitis with purulent peritonitis (Hinchey III) has traditionally been treated with surgery including colon resection and stoma (Hartmann procedure) with considerable postoperative morbidity and mortality. Laparoscopic lavage has been suggested as a less invasive surgical treatment. METHODS: Laparoscopic lavage was compared with colon resection and stoma in a randomized controlled multicenter trial, DILALA (ISRCTN82208287). Initial diagnostic laparoscopy showing Hinchey III was followed by randomization. Clinical data was collected up to 12 weeks postoperatively. Results: Eighty-three patients were randomized, out of whom 39 patients in laparoscopic lavage and 36 patients in the Hartmann procedure groups were available for analysis. Morbidity and mortality after laparoscopic lavage did not differ when compared with the Hartmann procedure. Laparoscopic lavage resulted in shorter operating time, shorter time in the recovery unit, and shorter hospital stay. CONCLUSIONS: In this trial, laparoscopic lavage as treatment for patients with perforated diverticulitis Hinchey III was feasible and safe in the short-term. Lippincott, Williams, and Wilkins 2016-01 2015-12-16 /pmc/articles/PMC4679345/ /pubmed/25489672 http://dx.doi.org/10.1097/SLA.0000000000001061 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Original Articles
Angenete, Eva
Thornell, Anders
Burcharth, Jakob
Pommergaard, Hans-Christian
Skullman, Stefan
Bisgaard, Thue
Jess, Per
Läckberg, Zoltan
Matthiessen, Peter
Heath, Jane
Rosenberg, Jacob
Haglind, Eva
Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA
title Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA
title_full Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA
title_fullStr Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA
title_full_unstemmed Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA
title_short Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA
title_sort laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results from the randomized controlled trial dilala
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679345/
https://www.ncbi.nlm.nih.gov/pubmed/25489672
http://dx.doi.org/10.1097/SLA.0000000000001061
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